import * as t from 'io-ts';
import { IMeta } from './RTTI_Meta';
import { IElement } from './RTTI_Element';
import { INarrative } from './RTTI_Narrative';
import { IResourceList } from '../Union/RTTI_ResourceList';
import { IExtension } from './RTTI_Extension';
import { IIdentifier } from './RTTI_Identifier';
import { ICodeableConcept } from './RTTI_CodeableConcept';
import { IReference } from './RTTI_Reference';
import { IContactDetail } from './RTTI_ContactDetail';
import { IUsageContext } from './RTTI_UsageContext';
import { IPeriod } from './RTTI_Period';
import { IRelatedArtifact } from './RTTI_RelatedArtifact';
import { IResearchElementDefinition_Characteristic } from './RTTI_ResearchElementDefinition_Characteristic';
export declare enum ResearchElementDefinitionStatusKind {
    _draft = "draft",
    _active = "active",
    _retired = "retired",
    _unknown = "unknown"
}
export declare enum ResearchElementDefinitionTypeKind {
    _population = "population",
    _exposure = "exposure",
    _outcome = "outcome"
}
export declare enum ResearchElementDefinitionVariableTypeKind {
    _dichotomous = "dichotomous",
    _continuous = "continuous",
    _descriptive = "descriptive"
}
import { IDomainResource } from './IDomainResource';
export interface IResearchElementDefinition extends IDomainResource {
    resourceType: 'ResearchElementDefinition';
    characteristic: IResearchElementDefinition_Characteristic[];
    id?: string;
    meta?: IMeta;
    implicitRules?: string;
    _implicitRules?: IElement;
    language?: string;
    _language?: IElement;
    text?: INarrative;
    contained?: IResourceList[];
    extension?: IExtension[];
    modifierExtension?: IExtension[];
    url?: string;
    _url?: IElement;
    identifier?: IIdentifier[];
    version?: string;
    _version?: IElement;
    name?: string;
    _name?: IElement;
    title?: string;
    _title?: IElement;
    shortTitle?: string;
    _shortTitle?: IElement;
    subtitle?: string;
    _subtitle?: IElement;
    status?: ResearchElementDefinitionStatusKind;
    _status?: IElement;
    experimental?: boolean;
    _experimental?: IElement;
    subjectCodeableConcept?: ICodeableConcept;
    subjectReference?: IReference;
    date?: string;
    _date?: IElement;
    publisher?: string;
    _publisher?: IElement;
    contact?: IContactDetail[];
    description?: string;
    _description?: IElement;
    comment?: string[];
    _comment?: IElement[];
    useContext?: IUsageContext[];
    jurisdiction?: ICodeableConcept[];
    purpose?: string;
    _purpose?: IElement;
    usage?: string;
    _usage?: IElement;
    copyright?: string;
    _copyright?: IElement;
    approvalDate?: string;
    _approvalDate?: IElement;
    lastReviewDate?: string;
    _lastReviewDate?: IElement;
    effectivePeriod?: IPeriod;
    topic?: ICodeableConcept[];
    author?: IContactDetail[];
    editor?: IContactDetail[];
    reviewer?: IContactDetail[];
    endorser?: IContactDetail[];
    relatedArtifact?: IRelatedArtifact[];
    library?: string[];
    type?: ResearchElementDefinitionTypeKind;
    _type?: IElement;
    variableType?: ResearchElementDefinitionVariableTypeKind;
    _variableType?: IElement;
}
export declare const RTTI_ResearchElementDefinition: t.Type<IResearchElementDefinition>;