import * as t from 'io-ts';
import { IMeta } from './RTTI_Meta';
import { IElement } from './RTTI_Element';
import { INarrative } from './RTTI_Narrative';
import { IResourceList } from '../Union/RTTI_ResourceList';
import { IExtension } from './RTTI_Extension';
import { IIdentifier } from './RTTI_Identifier';
import { IReference } from './RTTI_Reference';
import { ICodeableConcept } from './RTTI_CodeableConcept';
import { IContactDetail } from './RTTI_ContactDetail';
import { IRelatedArtifact } from './RTTI_RelatedArtifact';
import { IPeriod } from './RTTI_Period';
import { IAnnotation } from './RTTI_Annotation';
import { IResearchStudy_Arm } from './RTTI_ResearchStudy_Arm';
import { IResearchStudy_Objective } from './RTTI_ResearchStudy_Objective';
export declare enum ResearchStudyStatusKind {
    _active = "active",
    _administrativelyCompleted = "administratively-completed",
    _approved = "approved",
    _closedToAccrual = "closed-to-accrual",
    _closedToAccrualAndIntervention = "closed-to-accrual-and-intervention",
    _completed = "completed",
    _disapproved = "disapproved",
    _inReview = "in-review",
    _temporarilyClosedToAccrual = "temporarily-closed-to-accrual",
    _temporarilyClosedToAccrualAndIntervention = "temporarily-closed-to-accrual-and-intervention",
    _withdrawn = "withdrawn"
}
import { IDomainResource } from './IDomainResource';
export interface IResearchStudy extends IDomainResource {
    resourceType: 'ResearchStudy';
    id?: string;
    meta?: IMeta;
    implicitRules?: string;
    _implicitRules?: IElement;
    language?: string;
    _language?: IElement;
    text?: INarrative;
    contained?: IResourceList[];
    extension?: IExtension[];
    modifierExtension?: IExtension[];
    identifier?: IIdentifier[];
    title?: string;
    _title?: IElement;
    protocol?: IReference[];
    partOf?: IReference[];
    status?: ResearchStudyStatusKind;
    _status?: IElement;
    primaryPurposeType?: ICodeableConcept;
    phase?: ICodeableConcept;
    category?: ICodeableConcept[];
    focus?: ICodeableConcept[];
    condition?: ICodeableConcept[];
    contact?: IContactDetail[];
    relatedArtifact?: IRelatedArtifact[];
    keyword?: ICodeableConcept[];
    location?: ICodeableConcept[];
    description?: string;
    _description?: IElement;
    enrollment?: IReference[];
    period?: IPeriod;
    sponsor?: IReference;
    principalInvestigator?: IReference;
    site?: IReference[];
    reasonStopped?: ICodeableConcept;
    note?: IAnnotation[];
    arm?: IResearchStudy_Arm[];
    objective?: IResearchStudy_Objective[];
}
export declare const RTTI_ResearchStudy: t.Type<IResearchStudy>;