LOCUS       NG_009246              12950 bp    DNA     linear   PRI 25-JUN-2013
DEFINITION  Homo sapiens glutathione S-transferase mu 1 (GSTM1), RefSeqGene on
            chromosome 1.
ACCESSION   NG_009246
VERSION     NG_009246.1  GI:219521909
KEYWORDS    RefSeq; RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000031.6 and AC000032.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Cytosolic and membrane-bound forms of glutathione
            S-transferase are encoded by two distinct supergene families. At
            present, eight distinct classes of the soluble cytoplasmic
            mammalian glutathione S-transferases have been identified: alpha,
            kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
            glutathione S-transferase that belongs to the mu class. The mu
            class of enzymes functions in the detoxification of electrophilic
            compounds, including carcinogens, therapeutic drugs, environmental
            toxins and products of oxidative stress, by conjugation with
            glutathione. The genes encoding the mu class of enzymes are
            organized in a gene cluster on chromosome 1p13.3 and are known to
            be highly polymorphic. These genetic variations can change an
            individual's susceptibility to carcinogens and toxins as well as
            affect the toxicity and efficacy of certain drugs. Null mutations
            of this class mu gene have been linked with an increase in a number
            of cancers, likely due to an increased susceptibility to
            environmental toxins and carcinogens. Multiple protein isoforms are
            encoded by transcript variants of this gene. [provided by RefSeq,
            Jul 2008].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5771              AC000031.6         1-5771              c
            5772-12950          AC000032.7         18237-25415         c
FEATURES             Location/Qualifiers
     source          1..12950
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            5001..10950
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /note="glutathione S-transferase mu 1"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:4632"
                     /db_xref="MIM:138350"
     mRNA            join(5001..5114,5375..5450,5878..5942,6253..6334,
                     6430..6530,7476..7571,7659..7769,10411..10950)
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /product="glutathione S-transferase mu 1, transcript
                     variant 1"
                     /transcript_id="NM_000561.3"
                     /db_xref="GI:215276995"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:4632"
                     /db_xref="MIM:138350"
     exon            5001..5114
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5079..5114,5375..5450,5878..5942,6253..6334,
                     6430..6530,7476..7571,7659..7769,10411..10500)
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /EC_number="2.5.1.18"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_000552.2"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione S-transferase M1; S-(hydroxyalkyl)glutathione
                     lyase; GST class-mu 1; glutathione S-alkyltransferase;
                     glutathione S-aryltransferase; glutathione
                     S-aralkyltransferase; HB subunit 4; GST HB subunit 4"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 1 isoform 1"
                     /protein_id="NP_000552.2"
                     /db_xref="GI:23065544"
                     /db_xref="CCDS:CCDS809.1"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:4632"
                     /db_xref="MIM:138350"
                     /translation="MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILEN
                     QTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLV
                     YDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
                     "
     exon            5375..5450
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            5878..5942
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     STS             6253..6525
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="RH64476"
                     /db_xref="UniSTS:87865"
     exon            6253..6334
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     STS             6297..6454
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="GDB:655882"
                     /db_xref="UniSTS:158567"
     exon            6430..6530
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            7476..7571
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            7659..7769
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     STS             10286..11032
                     /standard_name="G67222"
                     /db_xref="UniSTS:186432"
     exon            10411..10950
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     STS             10594..10942
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="SHGC-12332"
                     /db_xref="UniSTS:33074"
     STS             10594..10880
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /db_xref="UniSTS:33073"
     STS             10632..10780
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="G62022"
                     /db_xref="UniSTS:139106"
ORIGIN      
        1 ttcagatttc ctaagtttac ccaaacaata tttaagagac tttaatacat ttccatgaat
       61 taggatacat tttattttgt ctgtcagtat ttgtttctaa tagattagtt tttaaaattc
      121 tgacaacatg ttaggtagat tttctgttaa tttgccttga gaatgtaaga atgttgtcag
      181 aagagacaga aggaattatg aattccagtc cagaggtccc attacaggcc cttggtaaag
      241 tgggacccag tgcattttga ctgtctggca cagcattgtt ttaaaaatta gaacttttcc
      301 acattttgca gttcagacag cacatacaaa tgcagaagtc caggccctgt cgggactgag
      361 tttctgtgtg gtgacaactg gctacaaccc cttccttctg aacacttgca gcttccctca
      421 tccctgctgc tcctgatccc cgtccacaga cccactttcc ccgctggtgt gatccttgtg
      481 gccactatgg cagctacttt ggagagccgc tagtccagtc cttcccgcct tccgcagagc
      541 tctactcctg cttctgaaga agccacctgg ggcctggcct tcttcctggc tcctcagagt
      601 ccttgcaaca gcaggcacta cttctctctc ctgcactcaa cccctctccc actccactgc
      661 ctctcagtgt gccaaaacac gaagatgtgt cctgattttc aaaatctctc ccctgaagtt
      721 cccacctgat atgtagttgg agatgggcaa atacagcgtc cttgaagcat cattttattc
      781 atagtgcctg gaatgtagta ggatctcgac aattgttgtt tcaataaagg aatgaccaaa
      841 tatattaata ctgtaaaaag taaagtagag gttcctcttc aaagagactt ttctccccat
      901 ctaattaaga ataagtcgta acttctctta gaagcaaaat ttattcaaag accggtgctg
      961 atattctgaa atatctgcta gctgtaataa agaaattaat gtactttatg ttcttaactc
     1021 ccacaattta gcctaaatac ttgccctggc atgcttatac tgatccaaac aagcatgagg
     1081 tcatagcctg ttcctcttcc ttatttgaag gtgtttttac cttactcagc attccacaag
     1141 tgagttcccc cttcctttgt tctcctctgc ctctgcctct tttaaaaagt tctaagttgc
     1201 tagccaatca ggacaaatac agaatgtgag gtcccgttcc agccagtgga aactggacac
     1261 agcagtaggg tggacacatc aagttataaa tgaccctttc tcctttgttc agtgtactct
     1321 cgtggtaaaa ctgctggcga gtgtaccctt tctgcagaaa gtaaaaatgg cctttgttgc
     1381 aggaagtcag ggaccccgaa cggagggacc ggctggagct gcagcagagg aacataaatt
     1441 gcaaatattt cattttaata tggacattta tcagttccca aattaatact tttataattt
     1501 cttatgcctg ccttacttta atctcttaat cctgttatct tcttaagctg aggatatagg
     1561 tcacctcagg accactgtga taattgtgtt aactgtacaa attgattgta aaacatgtgt
     1621 gtttgaacaa tatgaaatca gtgcaccttg aaaaagaaca gaataacagc gatttttagg
     1681 gaacaagaga agacaaccat aaggtctgac tgtccgcagg gtcgggcaaa atagagccat
     1741 gtttttcttc ttgcagagag cctataaatg gacatgcaag tagggaagat attgctaaat
     1801 tcttttccta gcagggaata ttaatattaa tactctggga aaggaatgca ttcctggggg
     1861 gaggtctata aacagccgct ttgggaatga atgactgtcc tatgcagttg agataaggac
     1921 tgaaatacac cccggtctcc tgcagtaccc tcaggtgggg aaaaaacctg gccctggcaa
     1981 atttgtggtc agactggttc tctgctcttg aaccctgtgt tctgttgttt aagatgttta
     2041 tcaagacaat atgtgcacca ctgaacatag acccttatca ggagttctac ttttgccttt
     2101 gtcctgtttc ctcagaagca tgtgatcttt gttctgcttt ttgcccttta aagcatgtga
     2161 tcttcgtacc taccctctgt tcgtacacca ccaccccttt tgcaatcctt aataaaaact
     2221 tgctggtttt gaggctcggg caggcatcat ggtcctaccg atatgtgatg tcacccctgg
     2281 cggcccagct gtaaaattct tctctttgta ctctttctct ttatttctca gctggctgac
     2341 acttatggaa aatagaaaga acctacgttg aaatattggg ggcaggttcc ccaatagcct
     2401 tgctgaggaa attaaattta tgttcaagtg ctatttcttt atggcaccaa ggaacaagta
     2461 tttcaaacaa tactaatgta acagtactgg ttctatgtgt ttcaaaatta ttattctcat
     2521 gagtgttagc tttcttaaaa aatcgttttt tttttcaatt ggatctagac atcttatctt
     2581 tcacagctca agacggatta actcagaatc ataaactctt aatgcataat gagaaatata
     2641 atgtttccta gggccaggca cttgtgtctg tgctggtgct attgcctcaa tgcaggaaaa
     2701 tctatgtaag agttcactgt gaggccaaaa ctgcttccta aacatggata cctgccaggt
     2761 atctgagctg ggagtactgc ccaggtctgg atgggcgggg agtgtttgca acaaggactg
     2821 tgccttgcca gcctcagtga cacagtgtcc aagtgcccca acttagcagc cacctgctga
     2881 ccacctgatt tctgtggcct aatagggatg tgatgaagtc tacctgttta ctcaacccca
     2941 aaccacacat tatccaggtg gtttgaaact tttttgatat actgggttca tcctctggag
     3001 tcctaacaat gttttagcta atttacaaaa aacaaaacaa aacaaaacaa aacaaaacaa
     3061 aacaaaaaaa ctactttttt tgcagcacaa cagcctggtt tacattgcaa aatgatttct
     3121 cattaaaggt ctatcatcta tttccatatg tccattatta tttgcaatat cctttaaagc
     3181 agtcaacccc aggctaatcc attgcacaac tcttttgaaa gtcttccttc taccttgaaa
     3241 gaagaaagtt ggcaggttgg acattgttct cgtggaggtt gtaccatggg tcacatatca
     3301 cggtgtgact tcaaaggcca ctggagccac cgtctcatac tgaagaacac acatgggtca
     3361 ggagccaggt ccaggtccgg aatggtggat ctggagaggg gagggtccct gcctgtggtc
     3421 ctgtggggag ccctcaggct cctctctggc caccatcctc tgacctccct cctcagcagg
     3481 acagggttct ggcttctctg agggacaggt tctgtggcag gccaggcgtc actaacacag
     3541 gcctccataa caactgtttc agtactgact gagtggtgaa gttaaatatt aaaagctgaa
     3601 aaaagccagt acctttatac agaggctgga tgtaacaaaa gcccaccaag agttttgctt
     3661 aggcctttcc tgggccttaa agcatgacaa aacaatgaag gaattcttaa caggacctat
     3721 ttagaattaa acaagtttta ttgtgagtct gaagaaactc cccaggcctc cacaaacaag
     3781 tttattgggc gtctgaagga actccccaaa cctccgtgat ttagcaggag acaagataag
     3841 ggtaatcatc ccccgcacct ggacccattt agattaaata aatagactga ggctccagaa
     3901 taaggtcctc aggacccaga cctcagttac agattaaaga agttaatcac ttatgtcttt
     3961 agatgaatgc acacttactt gtagacatat accttagaag gtatatatgc tctggaaaac
     4021 tttgtaatat tgagttggtc tggtggtaat ttctaggcct tctccctgtt accggttgca
     4081 gaaataaaac ctctcttcct ccccatttga tctgcatctc gttattgggc ctagagaaat
     4141 agcagccgga ccctcagttt ggtccgggaa gttcttccat cctccctcgc ctgctctctg
     4201 tggccactgc actcactgtt gctgttgctg ttccggtctc tgtgaggttc acctagtgga
     4261 ctggctggac atttctaggg ggcacctcag atacctcacc aacttgctgg atctgatcct
     4321 tggatttcga ttcataaatt gtgccaaaat acgaagtggc taatttacac agtacttagc
     4381 cagatgaccg aaggactcag tacccgaggg cccctaacag aaaacacaga ccacatttcc
     4441 tttactctgg cccttttcct gggggtcctt cctataccac tgacactgtt cctgtgtagg
     4501 cggggctaga ggggagacta agccctggga gtagctttcg gatcagagga agtcctgctc
     4561 ttacagtgac aggggctgaa ttaaattccc aggttggggc caccactttt tagtctgacc
     4621 cctgcagccg gagtctccca gagcccttgg gaactcggca gcggagagaa ggctgaggga
     4681 caccgcgggc agggaggaga agggagaaga gctttgctcc gttaggatct ggctggtgtc
     4741 tcaagcgcac agccaagtcg ctgtggacct agcaagggct ggatggactc gtggagcctc
     4801 agggctgggt agggaagctg gcgaggccga gccccgcctt gggcttctgg gcgccctgac
     4861 ttcgctcccg gaaccctcgg gcctgggagg cgggaggaag tcttactgag tgcagcccca
     4921 ggcgccctct cccgggcctc cagaatggcg cctttcgggt tgtggcgggc cgaggggcgg
     4981 ggtcgcagca aggccccgcc tgtcccctct ccggagctct tatactctga gccctgctcg
     5041 gtttaggcct gtctgcggaa tccgcaccaa ccagcaccat gcccatgata ctggggtact
     5101 gggacatccg cggggtgagc gagggtccgc tggacggtgg gacgagggcg caggggaggg
     5161 aagtgcgaag cagctgcggg acggactcta gggaccgttc ctcttcaggg ctgcccgcct
     5221 cagaagggcc tgtgcatgcc gctgtgtgtg tgttgggggt gtgggcgggt agaggaggca
     5281 acgggtacgt gcagtgtaaa ctgggggctt ccctggtgca gacaaagtca gggaccctcc
     5341 atctctgacg cgacctgcgg gccatctctc ccagctggcc cacgccatcc gcctgctcct
     5401 ggaatacaca gactcaagct atgaggaaaa gaagtacacg atgggggacg gtaatggcac
     5461 cctcgtgttc gggctctgcc cactcacgct aagttggcac caagcaaccc atggtggcca
     5521 cctgtggctg cctctgcagg cctcccctgc tggagctgca ggctgtctct tccctgagcc
     5581 ccggtgaggg agccctctgg ccttgcaagg cagaatgctg gggtgggatg ctgggccccc
     5641 tgtctaattg ggacgggtgt ccctcagggc ttgcctaaac cctggaagcc ttagctgtgt
     5701 ggggtccaga gccctcagcg ggattctttg tccctgaacc ctgggatgtg ggactgagtg
     5761 gtcagattct agatccacct gtctcaggga tcttgccact ggctccgtgg gagggtcccc
     5821 gggaaggagg gctgggctct ggggaggttt gttttcactt cttcttcccc accacagctc
     5881 ctgattatga cagaagccag tggctgaatg aaaaattcaa gctgggcctg gactttccca
     5941 atgtaggtgc aggggaaggg gcggttttgg gggaaagtgc aacgtgtctc tgactgcatc
     6001 tcctctcccc agcttagagg tgttaagatc aggagtcttc tgcccaattc ctctcactcc
     6061 tggctgtcta aacagtcctt ccatgatgtt ctgtgtccac ctgcattcgt tcatgtgaca
     6121 gtattcttat ttcagtcctg ccatgagcag gcacagtgag tgcccggtct cctctctgct
     6181 cttgcttatg ggaaggggat gctggggagc ctggtggccc aactgagctt cgccggtttc
     6241 ccatccatcc agctgcccta cttgattgat ggggctcaca agatcaccca gagcaacgcc
     6301 atcttgtgct acattgcccg caagcacaac ctgtgtgagt gtgggtggct gcaatgtgtg
     6361 gggggaaggt ggcctcctcc ttggctgggc tgtgatgctg agattgagtc tgtgttttgt
     6421 gggtggcagg tggggagaca gaagaggaga agattcgtgt ggacattttg gagaaccaga
     6481 ccatggacaa ccatatgcag ctgggcatga tctgctacaa tccagaattt gtgagtgtcc
     6541 ccagtgagct gcatctgaca gagtttggat ttggggccag gactcttgca ttcctgcaca
     6601 cactggtctt aagtccctgg taccattcat cctccaagtg ctttcccata ctatcagcag
     6661 ttattctcac gactccaatg tcatgtcaac aaaagcagag gcaattccca ccaaccttag
     6721 gacacgatcc aggcatccca gggtagaaat tcagttcctg tatggtaaag tttgtgttca
     6781 gaatctcctt catcagctct ggcctctgac ttctgtcctg ggtcatttct gtcagccagt
     6841 tcacatcacc tgcctgctcc tagaatatgc agactcaagt agaagactca ggaatgtaat
     6901 ggcaccctcg aattgcatct tctcctcaac agttttctga gtgctgtcat tgacatgcac
     6961 agggatctgc gcattttcat aacagacagc tcagaggcag tcagagggcc tttattcctc
     7021 tccctccttc ctttcaactt gaacttctca tctccctgga aactagtcaa tgttcattgt
     7081 tttcttctgc caccccatta gaaggaactt tctactttcc ctgagctccc ttagttcttt
     7141 gcatccttga ttctgctggt ctggatccag aggctgccag gtgcttgggc gctcctgggg
     7201 ctgacccaga ggctattggg aggtcagtga ggacagattc agggacagca tctcattcct
     7261 ctctgccttc tgatcagttt agatagggtc tggcactcag tcagagtcta ataaatgctg
     7321 atgtatccaa ttgaagcctg ggcactgccc cagttccagc ttggggaaga tggctgcttg
     7381 cccatggcca gcctgggccg tccacagccc cggggaggcc acgtctgtgc agggagcttt
     7441 tgtccgaggg tggtgacagc tgttttctgc ctcaggagaa actgaagcca aagtacttgg
     7501 aggaactccc tgaaaagcta aagctctact cagagtttct ggggaagcgg ccatggtttg
     7561 caggaaacaa ggtaaaggag gagtgatatg gggaatgaga tctgttttgc ttcacgtgtt
     7621 atggaggttc cagcccacat attcttggcc ttctgcagat cacttttgta gattttctcg
     7681 tctatgatgt ccttgacctc caccgtatat ttgagcccaa gtgcttggac gccttcccaa
     7741 atctgaagga cttcatctcc cgctttgagg tgatgccccc atcctccttt ctctttgatg
     7801 ccccttgttc cgttacctcc tttcagatgt tttcccagtc ctggagctac acacagaata
     7861 actcgcatgt attgagtact ggtttcatgc cacgaaccgt gcccagcaca ttatacctat
     7921 tgtgtgaaat ttgaatttta taacattcca gtaaggtaac agaattatct cgcccatttt
     7981 agagataagg aaactaagaa tgagagggtc agtcctttgc tcagggtccc agagctagtg
     8041 gaggctgtgc tgggctccct gtgagcctct ggatctatgg gtggcagtca gggctctccc
     8101 atttgtgaca gaagaaaaag ccttaggctt cacctagcct gggtttcaca gcccaggaca
     8161 ctttggaaga ggcagagaac ttcatgacca tagatggagc tggcaatagt aggactgaca
     8221 caacggtgac attgatgtct agtactgaac ccacaggcaa tattcatagc tacctccaga
     8281 agctttgcat gattggaccc cagtgtgggg aatcctgaga gccagggctg tggctgtagc
     8341 tggattaagg tacatatgtg ggtgtccctg ttgaaggagt atatgttgaa atgcccggtg
     8401 ctggggcact tccttactcc acctctattc tttttttttt tttttttttt tttttgtgct
     8461 ggagtcttgc tctgttgccc aggctggagt tcaatggagt gatcttggct cactgcaacc
     8521 tccgcctcct gggttcaagc gattctactg cctcagctgc acgattagtt gggattacag
     8581 gtgtgcacca ccacgtctgg ctaatttttg tatttttagt agagatgggg ttttgccatg
     8641 ttggtcaggc tggtctcgaa ctcctgacct caggtgatct gcccacatca gcctccctca
     8701 gtgctgggat tacagatatg agccactcct cttcctcttt tttccctcca gtgttccacg
     8761 tgttccccct gtgagatgag tagcatgctg attttactcc tattcaccga ccttctctgc
     8821 atgaggcagg gagtgaggca cagtgggaga tgtatagatg actgccccat cctggaaatg
     8881 agtgcagtga gagggctgca ggcagagcag cctgtgaggt gtgtgtggca ccacctgggt
     8941 accaggcccg gggcctgccc ctcactcacg gggaaccatc cctcaccctt gctgatcttg
     9001 tttcagagca caaatcctac tttagtacag atctgggaat ttgaggcatt agtccaacgg
     9061 gcttctgagc ctagaatctg tttccctttc ccatcaagaa atctgcttgc tcagctagtt
     9121 cccatcagct ctggttctgg tccaggctta gtggccttgg agttatgtaa gaggtggtgg
     9181 gaagggaggg gtggaggaga gctgaggtct atggcctatg acatgccagg gtcaatcagt
     9241 ttgagaacag gcagtcctgg atcttttttt tttttttttt tttgagatcg tgtcttgctg
     9301 ttgcccaggc tggagtgcag ttgcgtgacc tcggcttact gcaacctctg cctcccgggt
     9361 tcaaacaatt ctctgcctca gcctcccgag tagctgggat tacaagtgtc tatcaccacg
     9421 cccagctaat ttttctattt ttagtagaga tgggctttca ccatgttggc cagggtggtc
     9481 ttgaactcct gacctcgggt gatccaccca cctcggcttc ccaatgtgct gggattacag
     9541 gtgtgagccg gatgtttttg aataccttat ctgggcattc aatcctggta agattgtgca
     9601 cagcacatct gagtatcatg tagcctgatc tgcagcaggg ctggagatgc catgggttag
     9661 ggcacagtga gattttgctc aggtattaga tggagaactt tggactttct gctttaaggg
     9721 gaatgtttag agcctagtct cgcctttgat tttcttgtgc actgccaccc cccattccac
     9781 tttcatccag gttttactga gacattgggt gagtgtgttc agagcccctt tgttctgctg
     9841 gaggtccctt ctgtgtctct atacccagac aagccaagag cctccctgtg gaaaaggaga
     9901 ctgtttgtgc agtcaaggag tgacagggcc tggtgtgagg ggtggtgggg cagaagaaga
     9961 agagaatttg tcaggaagag gccagaactg gagagagaca gaaccaggct acactgcagt
    10021 tctattcccc ttactaggta tttaaatgta aggaagttgc tgaacttctg tttcccacat
    10081 gagaaatggt gataatagat tcagccttgc agagcagtcg agtgggtttt ctaagcttac
    10141 gttgtaattt ctcttgggta cagagcaccc agcaccgtgt agaatcttca taagtgttag
    10201 ctgttactgt ggtacaacat tacttaaagg aagttggaag agttaactcc gcaaatctgg
    10261 ggaccctaag aagctgtgtg atgcctcagc acttgagccc acatggaaag gctgtggcca
    10321 gggccctgac ctgctgtgtc tgcagtgggg ttgtcccagc cctcatgggc agctgacctt
    10381 gagttctggc cttattttcc cccctctcag ggcttggaga agatctctgc ctacatgaag
    10441 tccagccgct tcctcccaag acctgtgttc tcaaagatgg ctgtctgggg caacaagtag
    10501 ggccttgaag gccaggaggt gggagtgagg agcccatact cagcctgctg cccaggctgt
    10561 gcagcgcagc tggactctgc atcccagcac ctgcctcctc gttcctttct cctgtttatt
    10621 cccatcttta ctcccaagac ttcattgtcc ctcttcactc cccctaaacc cctgtcccat
    10681 gcaggccctt tgaagcctca gctacccact atccttcgtg aacatcccct cccatcatta
    10741 cccttccctg cactaaagcc agcctgacct tccttcctgt tagtggttgt gtctgcttta
    10801 aagggcctgc ctggcccctc gcctgtggag ctcagccccg agctgtcccc gtgttgcatg
    10861 aaggagcagc attgactggt ttacaggccc tgctcctgca gcatggtccc tgccttaggc
    10921 ctacctgatg gaagtaaagc ctcaaccaca tttgctgtgt gtcttgtctt atttgctcct
    10981 ggccatctac ccagactgtc tgtctgtctg tcactgcctc ttccaaggga ctggctggtg
    11041 atcctggcag tggctgggtt ctaaaggatt ctgctgggca tagtaaggcg cttgagaatt
    11101 cttgctccca ttcctgagag actcagagca ggaagcccca tgaggcactg tggaaaggat
    11161 gtctctttct tggcctggat gtcccattca ttcatccagc cgtattgagt actttccata
    11221 attgcacaga gcttgtgtct cattgaatag gaccccaagg gggtggaatc tccatcagag
    11281 agaaccaggg tcccttttac cttctccact atatgactac atcacttctg ttaggtctcc
    11341 aggacccaat ctctattgtt tttctcagat ggcttccagg taccctctcc aggcttgctg
    11401 cacagctgtc atcaggacgt tctctctggg tttacttcct ctctttcctg ggtacctgtg
    11461 agagaaatgt ctttagtcct tgcataactg aaagtgcctt tacatgctta ctgaatactc
    11521 tggctgagga tttagtctgt tctcacgctg ctaatagaga catacccgag actgggtaat
    11581 tgataaagga aagaggttta aaggtctcac agttccacag ggcctgggag gcctcataac
    11641 catggcagaa ggcgaatgag gaccaaagta atgtcttaca tggcagcagg gaagagggcg
    11701 tgtgcagggg aactcccact tataaaacca tcagatcttg tgagacttat tcactaccat
    11761 gagaacagta tgggggaaac tgcccccacg attcagtttt ctgcacccgg cccccaccct
    11821 tgatacctgg ggattattac aattcaaggt aagatgtggg tggtgacaca gccaaaccat
    11881 atcagctggg gatagaattc tatgatgaaa accttcagac ctctaataga tttactcgct
    11941 cttttctaga attgagcatt tctggtgagt aggtggatgc cagttctgac agcatctttt
    12001 gctttttaaa aattattatt attattttga gagggagtat tactctgtca cccaggctgg
    12061 agtgcagtgg tgtgatcttg tctcactgca acctcccctt cccaggttca aacgattctc
    12121 cttcctcagc ctcccaagta ggtggaacta taggcgcaca ccactgtgcc cagctaattt
    12181 ttgtattttt gttttagaga caggttttca ccgtgttggc caggctggtc tcaaactcct
    12241 gacctcgtga tccacccacc taggcctccc aaagttctgg aattacatgc gcgaactact
    12301 gcgcctgacc atatcttttg cttttttact taagcttttt ctgtttatca ttctgaggtc
    12361 tataattcca aaggccgtgt ggggatctac aggttgatct cttcctgact cacatcattg
    12421 caggaacttt ctaagcatag gcttcctcca ccctgacagc aatcccatat ctttatctgc
    12481 attgcatctt cttgaagtaa tttaaaatct cactggagag tgaactgctt cagaggaaga
    12541 ttctcatagc ttagcagttc ctaagctgtg ataccagaaa tagttgttga gtctgtgggt
    12601 caggtattca cgcaaggctc agcagggagt acttgttaca aatcaacaaa ggtctcttct
    12661 ccaaaaacta tatatccgaa aatacaactc attaaaaaat gagtcagaat ttcaacaagc
    12721 atttcccaaa agtgaatatc caaatggcca ctaagctcat gagaaggtgc tcaacatcat
    12781 tagacagcag aaagttaaaa acccctaaga tcctactgta tccccactag aatggctgat
    12841 attgaaagga ccgacaattg ttggtgattt atggagtaac tggaactgtc atgcattgct
    12901 ggtgggaaag ccactttgga atactggcac tgtcaactag agctaaacat
//

