LOCUS       NG_009246               5950 bp    DNA     linear   PRI 25-JUN-2013
DEFINITION  Homo sapiens glutathione S-transferase mu 1 (GSTM1), RefSeqGene on
            chromosome 1.
ACCESSION   NG_009246 REGION: 5001..10950
VERSION     NG_009246.1  GI:219521909
KEYWORDS    RefSeq; RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000031.6 and AC000032.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Cytosolic and membrane-bound forms of glutathione
            S-transferase are encoded by two distinct supergene families. At
            present, eight distinct classes of the soluble cytoplasmic
            mammalian glutathione S-transferases have been identified: alpha,
            kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
            glutathione S-transferase that belongs to the mu class. The mu
            class of enzymes functions in the detoxification of electrophilic
            compounds, including carcinogens, therapeutic drugs, environmental
            toxins and products of oxidative stress, by conjugation with
            glutathione. The genes encoding the mu class of enzymes are
            organized in a gene cluster on chromosome 1p13.3 and are known to
            be highly polymorphic. These genetic variations can change an
            individual's susceptibility to carcinogens and toxins as well as
            affect the toxicity and efficacy of certain drugs. Null mutations
            of this class mu gene have been linked with an increase in a number
            of cancers, likely due to an increased susceptibility to
            environmental toxins and carcinogens. Multiple protein isoforms are
            encoded by transcript variants of this gene. [provided by RefSeq,
            Jul 2008].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5771              AC000031.6         1-5771              c
            5772-12950          AC000032.7         18237-25415         c
FEATURES             Location/Qualifiers
     source          1..5950
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..5950
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /note="glutathione S-transferase mu 1"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:4632"
                     /db_xref="MIM:138350"
     mRNA            join(1..114,375..450,878..942,1253..1334,1430..1530,
                     2476..2571,2659..2769,5411..5950)
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /product="glutathione S-transferase mu 1, transcript
                     variant 1"
                     /transcript_id="NM_000561.3"
                     /db_xref="GI:215276995"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:4632"
                     /db_xref="MIM:138350"
     exon            1..114
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(79..114,375..450,878..942,1253..1334,1430..1530,
                     2476..2571,2659..2769,5411..5500)
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /EC_number="2.5.1.18"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_000552.2"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione S-transferase M1; S-(hydroxyalkyl)glutathione
                     lyase; GST class-mu 1; glutathione S-alkyltransferase;
                     glutathione S-aryltransferase; glutathione
                     S-aralkyltransferase; HB subunit 4; GST HB subunit 4"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 1 isoform 1"
                     /protein_id="NP_000552.2"
                     /db_xref="GI:23065544"
                     /db_xref="CCDS:CCDS809.1"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:4632"
                     /db_xref="MIM:138350"
                     /translation="MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILEN
                     QTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLV
                     YDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
                     "
     exon            375..450
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            878..942
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     STS             1253..1525
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="RH64476"
                     /db_xref="UniSTS:87865"
     exon            1253..1334
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     STS             1297..1454
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="GDB:655882"
                     /db_xref="UniSTS:158567"
     exon            1430..1530
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            2476..2571
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            2659..2769
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     STS             5286..>5950
                     /standard_name="G67222"
                     /db_xref="UniSTS:186432"
     exon            5411..5950
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     STS             5594..5942
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="SHGC-12332"
                     /db_xref="UniSTS:33074"
     STS             5594..5880
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /db_xref="UniSTS:33073"
     STS             5632..5780
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /standard_name="G62022"
                     /db_xref="UniSTS:139106"
ORIGIN      
        1 tgtcccctct ccggagctct tatactctga gccctgctcg gtttaggcct gtctgcggaa
       61 tccgcaccaa ccagcaccat gcccatgata ctggggtact gggacatccg cggggtgagc
      121 gagggtccgc tggacggtgg gacgagggcg caggggaggg aagtgcgaag cagctgcggg
      181 acggactcta gggaccgttc ctcttcaggg ctgcccgcct cagaagggcc tgtgcatgcc
      241 gctgtgtgtg tgttgggggt gtgggcgggt agaggaggca acgggtacgt gcagtgtaaa
      301 ctgggggctt ccctggtgca gacaaagtca gggaccctcc atctctgacg cgacctgcgg
      361 gccatctctc ccagctggcc cacgccatcc gcctgctcct ggaatacaca gactcaagct
      421 atgaggaaaa gaagtacacg atgggggacg gtaatggcac cctcgtgttc gggctctgcc
      481 cactcacgct aagttggcac caagcaaccc atggtggcca cctgtggctg cctctgcagg
      541 cctcccctgc tggagctgca ggctgtctct tccctgagcc ccggtgaggg agccctctgg
      601 ccttgcaagg cagaatgctg gggtgggatg ctgggccccc tgtctaattg ggacgggtgt
      661 ccctcagggc ttgcctaaac cctggaagcc ttagctgtgt ggggtccaga gccctcagcg
      721 ggattctttg tccctgaacc ctgggatgtg ggactgagtg gtcagattct agatccacct
      781 gtctcaggga tcttgccact ggctccgtgg gagggtcccc gggaaggagg gctgggctct
      841 ggggaggttt gttttcactt cttcttcccc accacagctc ctgattatga cagaagccag
      901 tggctgaatg aaaaattcaa gctgggcctg gactttccca atgtaggtgc aggggaaggg
      961 gcggttttgg gggaaagtgc aacgtgtctc tgactgcatc tcctctcccc agcttagagg
     1021 tgttaagatc aggagtcttc tgcccaattc ctctcactcc tggctgtcta aacagtcctt
     1081 ccatgatgtt ctgtgtccac ctgcattcgt tcatgtgaca gtattcttat ttcagtcctg
     1141 ccatgagcag gcacagtgag tgcccggtct cctctctgct cttgcttatg ggaaggggat
     1201 gctggggagc ctggtggccc aactgagctt cgccggtttc ccatccatcc agctgcccta
     1261 cttgattgat ggggctcaca agatcaccca gagcaacgcc atcttgtgct acattgcccg
     1321 caagcacaac ctgtgtgagt gtgggtggct gcaatgtgtg gggggaaggt ggcctcctcc
     1381 ttggctgggc tgtgatgctg agattgagtc tgtgttttgt gggtggcagg tggggagaca
     1441 gaagaggaga agattcgtgt ggacattttg gagaaccaga ccatggacaa ccatatgcag
     1501 ctgggcatga tctgctacaa tccagaattt gtgagtgtcc ccagtgagct gcatctgaca
     1561 gagtttggat ttggggccag gactcttgca ttcctgcaca cactggtctt aagtccctgg
     1621 taccattcat cctccaagtg ctttcccata ctatcagcag ttattctcac gactccaatg
     1681 tcatgtcaac aaaagcagag gcaattccca ccaaccttag gacacgatcc aggcatccca
     1741 gggtagaaat tcagttcctg tatggtaaag tttgtgttca gaatctcctt catcagctct
     1801 ggcctctgac ttctgtcctg ggtcatttct gtcagccagt tcacatcacc tgcctgctcc
     1861 tagaatatgc agactcaagt agaagactca ggaatgtaat ggcaccctcg aattgcatct
     1921 tctcctcaac agttttctga gtgctgtcat tgacatgcac agggatctgc gcattttcat
     1981 aacagacagc tcagaggcag tcagagggcc tttattcctc tccctccttc ctttcaactt
     2041 gaacttctca tctccctgga aactagtcaa tgttcattgt tttcttctgc caccccatta
     2101 gaaggaactt tctactttcc ctgagctccc ttagttcttt gcatccttga ttctgctggt
     2161 ctggatccag aggctgccag gtgcttgggc gctcctgggg ctgacccaga ggctattggg
     2221 aggtcagtga ggacagattc agggacagca tctcattcct ctctgccttc tgatcagttt
     2281 agatagggtc tggcactcag tcagagtcta ataaatgctg atgtatccaa ttgaagcctg
     2341 ggcactgccc cagttccagc ttggggaaga tggctgcttg cccatggcca gcctgggccg
     2401 tccacagccc cggggaggcc acgtctgtgc agggagcttt tgtccgaggg tggtgacagc
     2461 tgttttctgc ctcaggagaa actgaagcca aagtacttgg aggaactccc tgaaaagcta
     2521 aagctctact cagagtttct ggggaagcgg ccatggtttg caggaaacaa ggtaaaggag
     2581 gagtgatatg gggaatgaga tctgttttgc ttcacgtgtt atggaggttc cagcccacat
     2641 attcttggcc ttctgcagat cacttttgta gattttctcg tctatgatgt ccttgacctc
     2701 caccgtatat ttgagcccaa gtgcttggac gccttcccaa atctgaagga cttcatctcc
     2761 cgctttgagg tgatgccccc atcctccttt ctctttgatg ccccttgttc cgttacctcc
     2821 tttcagatgt tttcccagtc ctggagctac acacagaata actcgcatgt attgagtact
     2881 ggtttcatgc cacgaaccgt gcccagcaca ttatacctat tgtgtgaaat ttgaatttta
     2941 taacattcca gtaaggtaac agaattatct cgcccatttt agagataagg aaactaagaa
     3001 tgagagggtc agtcctttgc tcagggtccc agagctagtg gaggctgtgc tgggctccct
     3061 gtgagcctct ggatctatgg gtggcagtca gggctctccc atttgtgaca gaagaaaaag
     3121 ccttaggctt cacctagcct gggtttcaca gcccaggaca ctttggaaga ggcagagaac
     3181 ttcatgacca tagatggagc tggcaatagt aggactgaca caacggtgac attgatgtct
     3241 agtactgaac ccacaggcaa tattcatagc tacctccaga agctttgcat gattggaccc
     3301 cagtgtgggg aatcctgaga gccagggctg tggctgtagc tggattaagg tacatatgtg
     3361 ggtgtccctg ttgaaggagt atatgttgaa atgcccggtg ctggggcact tccttactcc
     3421 acctctattc tttttttttt tttttttttt tttttgtgct ggagtcttgc tctgttgccc
     3481 aggctggagt tcaatggagt gatcttggct cactgcaacc tccgcctcct gggttcaagc
     3541 gattctactg cctcagctgc acgattagtt gggattacag gtgtgcacca ccacgtctgg
     3601 ctaatttttg tatttttagt agagatgggg ttttgccatg ttggtcaggc tggtctcgaa
     3661 ctcctgacct caggtgatct gcccacatca gcctccctca gtgctgggat tacagatatg
     3721 agccactcct cttcctcttt tttccctcca gtgttccacg tgttccccct gtgagatgag
     3781 tagcatgctg attttactcc tattcaccga ccttctctgc atgaggcagg gagtgaggca
     3841 cagtgggaga tgtatagatg actgccccat cctggaaatg agtgcagtga gagggctgca
     3901 ggcagagcag cctgtgaggt gtgtgtggca ccacctgggt accaggcccg gggcctgccc
     3961 ctcactcacg gggaaccatc cctcaccctt gctgatcttg tttcagagca caaatcctac
     4021 tttagtacag atctgggaat ttgaggcatt agtccaacgg gcttctgagc ctagaatctg
     4081 tttccctttc ccatcaagaa atctgcttgc tcagctagtt cccatcagct ctggttctgg
     4141 tccaggctta gtggccttgg agttatgtaa gaggtggtgg gaagggaggg gtggaggaga
     4201 gctgaggtct atggcctatg acatgccagg gtcaatcagt ttgagaacag gcagtcctgg
     4261 atcttttttt tttttttttt tttgagatcg tgtcttgctg ttgcccaggc tggagtgcag
     4321 ttgcgtgacc tcggcttact gcaacctctg cctcccgggt tcaaacaatt ctctgcctca
     4381 gcctcccgag tagctgggat tacaagtgtc tatcaccacg cccagctaat ttttctattt
     4441 ttagtagaga tgggctttca ccatgttggc cagggtggtc ttgaactcct gacctcgggt
     4501 gatccaccca cctcggcttc ccaatgtgct gggattacag gtgtgagccg gatgtttttg
     4561 aataccttat ctgggcattc aatcctggta agattgtgca cagcacatct gagtatcatg
     4621 tagcctgatc tgcagcaggg ctggagatgc catgggttag ggcacagtga gattttgctc
     4681 aggtattaga tggagaactt tggactttct gctttaaggg gaatgtttag agcctagtct
     4741 cgcctttgat tttcttgtgc actgccaccc cccattccac tttcatccag gttttactga
     4801 gacattgggt gagtgtgttc agagcccctt tgttctgctg gaggtccctt ctgtgtctct
     4861 atacccagac aagccaagag cctccctgtg gaaaaggaga ctgtttgtgc agtcaaggag
     4921 tgacagggcc tggtgtgagg ggtggtgggg cagaagaaga agagaatttg tcaggaagag
     4981 gccagaactg gagagagaca gaaccaggct acactgcagt tctattcccc ttactaggta
     5041 tttaaatgta aggaagttgc tgaacttctg tttcccacat gagaaatggt gataatagat
     5101 tcagccttgc agagcagtcg agtgggtttt ctaagcttac gttgtaattt ctcttgggta
     5161 cagagcaccc agcaccgtgt agaatcttca taagtgttag ctgttactgt ggtacaacat
     5221 tacttaaagg aagttggaag agttaactcc gcaaatctgg ggaccctaag aagctgtgtg
     5281 atgcctcagc acttgagccc acatggaaag gctgtggcca gggccctgac ctgctgtgtc
     5341 tgcagtgggg ttgtcccagc cctcatgggc agctgacctt gagttctggc cttattttcc
     5401 cccctctcag ggcttggaga agatctctgc ctacatgaag tccagccgct tcctcccaag
     5461 acctgtgttc tcaaagatgg ctgtctgggg caacaagtag ggccttgaag gccaggaggt
     5521 gggagtgagg agcccatact cagcctgctg cccaggctgt gcagcgcagc tggactctgc
     5581 atcccagcac ctgcctcctc gttcctttct cctgtttatt cccatcttta ctcccaagac
     5641 ttcattgtcc ctcttcactc cccctaaacc cctgtcccat gcaggccctt tgaagcctca
     5701 gctacccact atccttcgtg aacatcccct cccatcatta cccttccctg cactaaagcc
     5761 agcctgacct tccttcctgt tagtggttgt gtctgcttta aagggcctgc ctggcccctc
     5821 gcctgtggag ctcagccccg agctgtcccc gtgttgcatg aaggagcagc attgactggt
     5881 ttacaggccc tgctcctgca gcatggtccc tgccttaggc ctacctgatg gaagtaaagc
     5941 ctcaaccaca
//

