import { ModuleObject, RdkitInstance, RdkitModule } from '../types';
/**
 * @private
 * @returns {RdkitInstance}
 * @throws rdkit.js is not initialised.
 */
export declare const getInstance: () => RdkitInstance;
/**
 * @returns {boolean} if the rdkit module is initialised
 */
export declare function isInitialised(): boolean;
/**
 * Initialises the WebAssembly backend.
 * Needs to be called and finished before any other methods or classes can be used.
 * If no fileLocation is provided it assumes that the rdkit.wasm file is in the same directory as the rdkitjs.(cjs|esm).js file
 *
 * @async
 * @param {Function} rdkitModule module to use to initialise wasm (full or mini)
 * @param {string} fileLocation either the wasm path
 */
export declare function initialise(rdkitModule: (moduleObject: ModuleObject) => Promise<RdkitModule>, fileLocation?: string): Promise<void>;