// SPDX-FileCopyrightText: Copyright Orangebot, Inc. and Medplum contributors
// SPDX-License-Identifier: Apache-2.0
/*
 * This is a generated file
 * Do not edit manually.
 */

import type { CodeableConcept } from './CodeableConcept.d.ts';
import type { ContactDetail } from './ContactDetail.d.ts';
import type { DataRequirement } from './DataRequirement.d.ts';
import type { Duration } from './Duration.d.ts';
import type { Expression } from './Expression.d.ts';
import type { Extension } from './Extension.d.ts';
import type { Group } from './Group.d.ts';
import type { Identifier } from './Identifier.d.ts';
import type { Meta } from './Meta.d.ts';
import type { Narrative } from './Narrative.d.ts';
import type { Period } from './Period.d.ts';
import type { Reference } from './Reference.d.ts';
import type { RelatedArtifact } from './RelatedArtifact.d.ts';
import type { Resource } from './Resource.d.ts';
import type { Timing } from './Timing.d.ts';
import type { UsageContext } from './UsageContext.d.ts';

/**
 * The ResearchElementDefinition resource describes a "PICO" element that
 * knowledge (evidence, assertion, recommendation) is about.
 */
export interface ResearchElementDefinition {

  /**
   * This is a ResearchElementDefinition resource
   */
  readonly resourceType: 'ResearchElementDefinition';

  /**
   * The logical id of the resource, as used in the URL for the resource.
   * Once assigned, this value never changes.
   */
  id?: string;

  /**
   * The metadata about the resource. This is content that is maintained by
   * the infrastructure. Changes to the content might not always be
   * associated with version changes to the resource.
   */
  meta?: Meta;

  /**
   * A reference to a set of rules that were followed when the resource was
   * constructed, and which must be understood when processing the content.
   * Often, this is a reference to an implementation guide that defines the
   * special rules along with other profiles etc.
   */
  implicitRules?: string;

  /**
   * The base language in which the resource is written.
   */
  language?: string;

  /**
   * A human-readable narrative that contains a summary of the resource and
   * can be used to represent the content of the resource to a human. The
   * narrative need not encode all the structured data, but is required to
   * contain sufficient detail to make it "clinically safe" for a human to
   * just read the narrative. Resource definitions may define what content
   * should be represented in the narrative to ensure clinical safety.
   */
  text?: Narrative;

  /**
   * These resources do not have an independent existence apart from the
   * resource that contains them - they cannot be identified independently,
   * and nor can they have their own independent transaction scope.
   */
  contained?: Resource[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the resource. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the resource and that modifies the
   * understanding of the element that contains it and/or the understanding
   * of the containing element's descendants. Usually modifier elements
   * provide negation or qualification. To make the use of extensions safe
   * and manageable, there is a strict set of governance applied to the
   * definition and use of extensions. Though any implementer is allowed to
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension. Applications processing a
   * resource are required to check for modifier extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * An absolute URI that is used to identify this research element
   * definition when it is referenced in a specification, model, design or
   * an instance; also called its canonical identifier. This SHOULD be
   * globally unique and SHOULD be a literal address at which at which an
   * authoritative instance of this research element definition is (or will
   * be) published. This URL can be the target of a canonical reference. It
   * SHALL remain the same when the research element definition is stored
   * on different servers.
   */
  url?: string;

  /**
   * A formal identifier that is used to identify this research element
   * definition when it is represented in other formats, or referenced in a
   * specification, model, design or an instance.
   */
  identifier?: Identifier[];

  /**
   * The identifier that is used to identify this version of the research
   * element definition when it is referenced in a specification, model,
   * design or instance. This is an arbitrary value managed by the research
   * element definition author and is not expected to be globally unique.
   * For example, it might be a timestamp (e.g. yyyymmdd) if a managed
   * version is not available. There is also no expectation that versions
   * can be placed in a lexicographical sequence. To provide a version
   * consistent with the Decision Support Service specification, use the
   * format Major.Minor.Revision (e.g. 1.0.0). For more information on
   * versioning knowledge assets, refer to the Decision Support Service
   * specification. Note that a version is required for non-experimental
   * active artifacts.
   */
  version?: string;

  /**
   * A natural language name identifying the research element definition.
   * This name should be usable as an identifier for the module by machine
   * processing applications such as code generation.
   */
  name?: string;

  /**
   * A short, descriptive, user-friendly title for the research element
   * definition.
   */
  title?: string;

  /**
   * The short title provides an alternate title for use in informal
   * descriptive contexts where the full, formal title is not necessary.
   */
  shortTitle?: string;

  /**
   * An explanatory or alternate title for the ResearchElementDefinition
   * giving additional information about its content.
   */
  subtitle?: string;

  /**
   * The status of this research element definition. Enables tracking the
   * life-cycle of the content.
   */
  status: 'draft' | 'active' | 'retired' | 'unknown';

  /**
   * A Boolean value to indicate that this research element definition is
   * authored for testing purposes (or education/evaluation/marketing) and
   * is not intended to be used for genuine usage.
   */
  experimental?: boolean;

  /**
   * The intended subjects for the ResearchElementDefinition. If this
   * element is not provided, a Patient subject is assumed, but the subject
   * of the ResearchElementDefinition can be anything.
   */
  subjectCodeableConcept?: CodeableConcept;

  /**
   * The intended subjects for the ResearchElementDefinition. If this
   * element is not provided, a Patient subject is assumed, but the subject
   * of the ResearchElementDefinition can be anything.
   */
  subjectReference?: Reference<Group>;

  /**
   * The date  (and optionally time) when the research element definition
   * was published. The date must change when the business version changes
   * and it must change if the status code changes. In addition, it should
   * change when the substantive content of the research element definition
   * changes.
   */
  date?: string;

  /**
   * The name of the organization or individual that published the research
   * element definition.
   */
  publisher?: string;

  /**
   * Contact details to assist a user in finding and communicating with the
   * publisher.
   */
  contact?: ContactDetail[];

  /**
   * A free text natural language description of the research element
   * definition from a consumer's perspective.
   */
  description?: string;

  /**
   * A human-readable string to clarify or explain concepts about the
   * resource.
   */
  comment?: string[];

  /**
   * The content was developed with a focus and intent of supporting the
   * contexts that are listed. These contexts may be general categories
   * (gender, age, ...) or may be references to specific programs
   * (insurance plans, studies, ...) and may be used to assist with
   * indexing and searching for appropriate research element definition
   * instances.
   */
  useContext?: UsageContext[];

  /**
   * A legal or geographic region in which the research element definition
   * is intended to be used.
   */
  jurisdiction?: CodeableConcept[];

  /**
   * Explanation of why this research element definition is needed and why
   * it has been designed as it has.
   */
  purpose?: string;

  /**
   * A detailed description, from a clinical perspective, of how the
   * ResearchElementDefinition is used.
   */
  usage?: string;

  /**
   * A copyright statement relating to the research element definition
   * and/or its contents. Copyright statements are generally legal
   * restrictions on the use and publishing of the research element
   * definition.
   */
  copyright?: string;

  /**
   * The date on which the resource content was approved by the publisher.
   * Approval happens once when the content is officially approved for
   * usage.
   */
  approvalDate?: string;

  /**
   * The date on which the resource content was last reviewed. Review
   * happens periodically after approval but does not change the original
   * approval date.
   */
  lastReviewDate?: string;

  /**
   * The period during which the research element definition content was or
   * is planned to be in active use.
   */
  effectivePeriod?: Period;

  /**
   * Descriptive topics related to the content of the
   * ResearchElementDefinition. Topics provide a high-level categorization
   * grouping types of ResearchElementDefinitions that can be useful for
   * filtering and searching.
   */
  topic?: CodeableConcept[];

  /**
   * An individiual or organization primarily involved in the creation and
   * maintenance of the content.
   */
  author?: ContactDetail[];

  /**
   * An individual or organization primarily responsible for internal
   * coherence of the content.
   */
  editor?: ContactDetail[];

  /**
   * An individual or organization primarily responsible for review of some
   * aspect of the content.
   */
  reviewer?: ContactDetail[];

  /**
   * An individual or organization responsible for officially endorsing the
   * content for use in some setting.
   */
  endorser?: ContactDetail[];

  /**
   * Related artifacts such as additional documentation, justification, or
   * bibliographic references.
   */
  relatedArtifact?: RelatedArtifact[];

  /**
   * A reference to a Library resource containing the formal logic used by
   * the ResearchElementDefinition.
   */
  library?: string[];

  /**
   * The type of research element, a population, an exposure, or an
   * outcome.
   */
  type: 'population' | 'exposure' | 'outcome';

  /**
   * The type of the outcome (e.g. Dichotomous, Continuous, or
   * Descriptive).
   */
  variableType?: 'dichotomous' | 'continuous' | 'descriptive';

  /**
   * A characteristic that defines the members of the research element.
   * Multiple characteristics are applied with &quot;and&quot; semantics.
   */
  characteristic: ResearchElementDefinitionCharacteristic[];
}

/**
 * The intended subjects for the ResearchElementDefinition. If this
 * element is not provided, a Patient subject is assumed, but the subject
 * of the ResearchElementDefinition can be anything.
 */
export type ResearchElementDefinitionSubject = CodeableConcept | Reference<Group>;

/**
 * A characteristic that defines the members of the research element.
 * Multiple characteristics are applied with &quot;and&quot; semantics.
 */
export interface ResearchElementDefinitionCharacteristic {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * Define members of the research element using Codes (such as condition,
   * medication, or observation), Expressions ( using an expression
   * language such as FHIRPath or CQL) or DataRequirements (such as
   * Diabetes diagnosis onset in the last year).
   */
  definitionCodeableConcept?: CodeableConcept;

  /**
   * Define members of the research element using Codes (such as condition,
   * medication, or observation), Expressions ( using an expression
   * language such as FHIRPath or CQL) or DataRequirements (such as
   * Diabetes diagnosis onset in the last year).
   */
  definitionCanonical?: string;

  /**
   * Define members of the research element using Codes (such as condition,
   * medication, or observation), Expressions ( using an expression
   * language such as FHIRPath or CQL) or DataRequirements (such as
   * Diabetes diagnosis onset in the last year).
   */
  definitionExpression?: Expression;

  /**
   * Define members of the research element using Codes (such as condition,
   * medication, or observation), Expressions ( using an expression
   * language such as FHIRPath or CQL) or DataRequirements (such as
   * Diabetes diagnosis onset in the last year).
   */
  definitionDataRequirement?: DataRequirement;

  /**
   * Use UsageContext to define the members of the population, such as Age
   * Ranges, Genders, Settings.
   */
  usageContext?: UsageContext[];

  /**
   * When true, members with this characteristic are excluded from the
   * element.
   */
  exclude?: boolean;

  /**
   * Specifies the UCUM unit for the outcome.
   */
  unitOfMeasure?: CodeableConcept;

  /**
   * A narrative description of the time period the study covers.
   */
  studyEffectiveDescription?: string;

  /**
   * Indicates what effective period the study covers.
   */
  studyEffectiveDateTime?: string;

  /**
   * Indicates what effective period the study covers.
   */
  studyEffectivePeriod?: Period;

  /**
   * Indicates what effective period the study covers.
   */
  studyEffectiveDuration?: Duration;

  /**
   * Indicates what effective period the study covers.
   */
  studyEffectiveTiming?: Timing;

  /**
   * Indicates duration from the study initiation.
   */
  studyEffectiveTimeFromStart?: Duration;

  /**
   * Indicates how elements are aggregated within the study effective
   * period.
   */
  studyEffectiveGroupMeasure?: 'mean' | 'median' | 'mean-of-mean' | 'mean-of-median' | 'median-of-mean' | 'median-of-median';

  /**
   * A narrative description of the time period the study covers.
   */
  participantEffectiveDescription?: string;

  /**
   * Indicates what effective period the study covers.
   */
  participantEffectiveDateTime?: string;

  /**
   * Indicates what effective period the study covers.
   */
  participantEffectivePeriod?: Period;

  /**
   * Indicates what effective period the study covers.
   */
  participantEffectiveDuration?: Duration;

  /**
   * Indicates what effective period the study covers.
   */
  participantEffectiveTiming?: Timing;

  /**
   * Indicates duration from the participant's study entry.
   */
  participantEffectiveTimeFromStart?: Duration;

  /**
   * Indicates how elements are aggregated within the study effective
   * period.
   */
  participantEffectiveGroupMeasure?: 'mean' | 'median' | 'mean-of-mean' | 'mean-of-median' | 'median-of-mean' | 'median-of-median';
}

/**
 * Define members of the research element using Codes (such as condition,
 * medication, or observation), Expressions ( using an expression
 * language such as FHIRPath or CQL) or DataRequirements (such as
 * Diabetes diagnosis onset in the last year).
 */
export type ResearchElementDefinitionCharacteristicDefinition = CodeableConcept | DataRequirement | Expression | string;

/**
 * Indicates what effective period the study covers.
 */
export type ResearchElementDefinitionCharacteristicStudyEffective = Duration | Period | string | Timing;

/**
 * Indicates what effective period the study covers.
 */
export type ResearchElementDefinitionCharacteristicParticipantEffective = Duration | Period | string | Timing;