Metabolic Process Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation. dbc acetylcholine metabolic pathway PW:0000408 Pathway Ontology 6867732 PubMed Choline and cholinergic neurons. Science 1983 Blusztajn JK Wurtman RJ