Metabolic Process The [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both [[wikipedia:Albert_Szent-Gyorgyi|Albert Szent-Gyorgyi]] and [[wikipedia:Hans_Krebs|Hans Krebs]]. Source: Wikipedia ([[wikipedia:citric_acid_cycle]]) e64 The ChEBI ID with the correct charge is: 37565 The ChEBI ID with the correct charge is: 58189 The ChEBI ID with the correct charge is: 57945 The ChEBI ID with the correct charge is: 15562 The ChEBI ID with the correct charge is: 57292 d25 The ChEBI ID with the correct charge is: 57288 The ChEBI ID with the correct charge is: 30031 The ChEBI ID with the correct charge is: 16383 The ChEBI ID with the correct charge is: 57945 The ChEBI ID with the correct charge is: 57783 The ChEBI ID with the correct charge is: 57287 Type your comment here The ChEBI ID with the correct charge is: 57945 The ChEBI ID with the correct charge is: 456216 The ChEBI ID with the correct charge is: 30616 The ChEBI ID with the correct charge is: 57287 The ChEBI ID with the correct charge is: 57287 Not all metabolic pathways of amino acids are connected to the TCa cycle. a4d ed6 ead af4 be3 af4 f8c b72 ea0 b56 a20 c21 c9e c21 c9e e8a 15234968 PubMed Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues. J Biol Chem 2004 Lambeth DO Tews KN Adkins S Frohlich D Milavetz BI 7730304 PubMed Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. J Biol Chem 1995 Des Rosiers C Di Donato L Comte B Laplante A Marcoux C David F Fernandez CA Brunengraber H 7060582 PubMed Citrate synthesis in intact rat-liver mitochondria is irreversible. Eur J Biochem 1982 Greksák M Lopes-Cardozo M van den Bergh SG 9765290 PubMed Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. J Biol Chem 1998 Johnson JD Muhonen WW Lambeth DO PubMed The Role of Citric Acid in Intermediate Metabolism in Animal Tissues. Enzymologia 1937 Krebs, H. A. Johnson, W. A. 8187868 PubMed Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS Lett 1994 Sazanov LA Jackson JB 3052428 PubMed Physiological roles of nicotinamide nucleotide transhydrogenase. Biochem J 1988 Hoek JB Rydström J 3724458 PubMed Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria. Metabolism 1986 Gabriel JL Zervos PR Plaut GW 7730305 PubMed Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates. J Biol Chem 1995 Fernandez CA Des Rosiers C TCA cycle PW:0000026 Pathway Ontology 12234803 PubMed Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia. Am J Physiol Heart Circ Physiol 2002 Comte B Vincent G Bouchard B Benderdour M Des Rosiers C 8506365 PubMed Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient. Proc Natl Acad Sci U S A 1993 Liu TC Kim H Arizmendi C Kitano A Patel MS 10672230 PubMed The alpha-ketoglutarate dehydrogenase complex. Ann N Y Acad Sci 1999 Sheu KF Blass JP 13018271 PubMed The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase. Biochem J 1952 13018271 PubMed The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase. Biochem J 1952 Krebs HA Holzach O citrate cycle pathway PW:0000026 Pathway Ontology 7961626 PubMed Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates. J Biol Chem 1994 Des Rosiers C Fernandez CA David F Brunengraber H 949837 PubMed Urinary organic acids in man. I. Normal patterns. Clin Chem 1976 Lawson AM Chalmers RA Watts RW