BiologicalEntity
type: Class
subclass of: Thing
is part of: schema.biothings.io

OntologyClass
type: Class
comment: a concept or class in an ontology, vocabulary or thesaurus
subclass of: Thing
is part of: schema.biothings.io

RelationshipType
type: Class
comment: An OWL property used as an edge label
subclass of: OntologyClass
is part of: schema.biothings.io

GeneOntologyClass
type: Class
comment: an ontology class that describes a functional aspect of a gene, gene prodoct or complex
subclass of: OntologyClass
is part of: schema.biothings.io

OrganismTaxon
type: Class
subclass of: OntologyClass
is part of: schema.biothings.io

OrganismalEntity
type: Class
comment: A named entity that is either a part of an organism, a whole organism, population or clade of organisms, excluding molecular entities
subclass of: BiologicalEntity
is part of: schema.biothings.io

IndividualOrganism
type: Class
subclass of: OrganismalEntity
is part of: schema.biothings.io

Case
type: Class
comment: An individual organism that has a patient role in some clinical context.
subclass of: IndividualOrganism
is part of: schema.biothings.io

PopulationOfIndividualOrganisms
type: Class
subclass of: OrganismalEntity
is part of: schema.biothings.io

Biosample
type: Class
subclass of: OrganismalEntity
is part of: schema.biothings.io

DiseaseOrPhenotypicFeature
type: Class
comment: Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate.
subclass of: BiologicalEntity
is part of: schema.biothings.io

Disease
type: Class
subclass of: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io

PhenotypicFeature
type: Class
subclass of: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io

Environment
type: Class
comment: A feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes
subclass of: BiologicalEntity
is part of: schema.biothings.io

InformationContentEntity
type: Class
comment: a piece of information that typically describes some piece of biology or is used as support.
subclass of: Thing
is part of: schema.biothings.io

ConfidenceLevel
type: Class
comment: Level of confidence in a statement
subclass of: InformationContentEntity
is part of: schema.biothings.io

EvidenceType
type: Class
comment: Class of evidence that supports an association
subclass of: InformationContentEntity
is part of: schema.biothings.io

Publication
type: Class
comment: Any published piece of information. Can refer to a whole publication, or to a part of it (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web as well as journals.
subclass of: InformationContentEntity
is part of: schema.biothings.io

MolecularEntity
type: Class
comment: A gene, gene product, small molecule or macromolecule (including protein complex)
subclass of: BiologicalEntity
is part of: schema.biothings.io

ChemicalSubstance
type: Class
comment: May be a chemical entity or a formulation with a chemical entity as active ingredient, or a complex material with multiple chemical entities as part
subclass of: MolecularEntity
is part of: schema.biothings.io

Drug
type: Class
comment: A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease
subclass of: ChemicalSubstance
is part of: schema.biothings.io

Metabolite
type: Class
comment: Any intermediate or product resulting from metabolism. Includes primary and secondary metabolites.
subclass of: ChemicalSubstance
is part of: schema.biothings.io

AnatomicalEntity
type: Class
comment: A subcellular location, cell type or gross anatomical part
subclass of: OrganismalEntity
is part of: schema.biothings.io

LifeStage
type: Class
comment: A stage of development or growth of an organism, including post-natal adult stages
subclass of: OrganismalEntity
is part of: schema.biothings.io

PlanetaryEntity
type: Class
comment: Any entity or process that exists at the level of the whole planet
subclass of: Thing
is part of: schema.biothings.io

EnvironmentalProcess
type: Class
subclass of: PlanetaryEntity
is part of: schema.biothings.io

EnvironmentalFeature
type: Class
subclass of: PlanetaryEntity
is part of: schema.biothings.io

ClinicalEntity
type: Class
comment: Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities
subclass of: Thing
is part of: schema.biothings.io

ClinicalTrial
type: Class
subclass of: ClinicalEntity
is part of: schema.biothings.io

ClinicalIntervention
type: Class
subclass of: ClinicalEntity
is part of: schema.biothings.io

Device
type: Class
comment: A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment
subclass of: Thing
is part of: schema.biothings.io

GenomicEntity
type: Class
comment: an entity that can either be directly located on a genome (gene, transcript, exon, regulatory region) or is encoded in a genome (protein)
subclass of: MolecularEntity
is part of: schema.biothings.io

Genome
type: Class
comment: A genome is the sum of genetic material within a cell or virion.
subclass of: GenomicEntity
is part of: schema.biothings.io

Transcript
type: Class
comment: An RNA synthesized on a DNA or RNA template by an RNA polymerase
subclass of: GenomicEntity
is part of: schema.biothings.io

Exon
type: Class
comment: A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing
subclass of: GenomicEntity
is part of: schema.biothings.io

CodingSequence
type: Class
subclass of: GenomicEntity
is part of: schema.biothings.io

MacromolecularMachine
type: Class
comment: A union of gene, gene product, and macromolecular complex. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this.
subclass of: GenomicEntity
is part of: schema.biothings.io

GeneOrGeneProduct
type: Class
comment: a union of genes or gene products. Frequently an identifier for one will be used as proxy for another
subclass of: MacromolecularMachine
is part of: schema.biothings.io

Gene
type: Class
subclass of: GeneOrGeneProduct
is part of: schema.biothings.io

GeneProduct
type: Class
comment: The functional molecular product of a single gene. Gene products are either proteins or functional RNA molecules
subclass of: GeneOrGeneProduct
is part of: schema.biothings.io

Protein
type: Class
comment: A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA
subclass of: GeneProduct
is part of: schema.biothings.io

GeneProductIsoform
type: Class
comment: This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms.
subclass of: GeneProduct
is part of: schema.biothings.io

ProteinIsoform
type: Class
comment: Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/
subclass of: Protein
is part of: schema.biothings.io

RnaProduct
type: Class
subclass of: GeneProduct
is part of: schema.biothings.io

RnaProductIsoform
type: Class
comment: Represents a protein that is a specific isoform of the canonical or reference RNA
subclass of: RnaProduct
is part of: schema.biothings.io

NoncodingRnaProduct
type: Class
subclass of: RnaProduct
is part of: schema.biothings.io

Microrna
type: Class
subclass of: NoncodingRnaProduct
is part of: schema.biothings.io

MacromolecularComplex
type: Class
subclass of: MacromolecularMachine
is part of: schema.biothings.io

GeneFamily
type: Class
comment: any grouping of multiple genes or gene products related by common descent
subclass of: MolecularEntity
is part of: schema.biothings.io

Genotype
type: Class
comment: An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some extablished background
subclass of: GenomicEntity
is part of: schema.biothings.io

Haplotype
type: Class
comment: A set of zero or more Alleles on a single instance of a Sequence[VMC]
subclass of: GenomicEntity
is part of: schema.biothings.io

SequenceVariant
type: Class
comment: An allele that varies in its sequence from what is considered the reference allele at that locus.
subclass of: GenomicEntity
is part of: schema.biothings.io

DrugExposure
type: Class
comment: A drug exposure is an intake of a particular chemical substance
subclass of: Environment
is part of: schema.biothings.io

Treatment
type: Class
comment: A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures'
subclass of: Environment
is part of: schema.biothings.io

GeographicLocation
type: Class
comment: a location that can be described in lat/long coordinates
subclass of: PlanetaryEntity
is part of: schema.biothings.io

GeographicLocationAtTime
type: Class
comment: a location that can be described in lat/long coordinates, for a particular time
subclass of: GeographicLocation
is part of: schema.biothings.io

Occurrent
type: Class
comment: A processual entity
subclass of: Thing
is part of: schema.biothings.io

BiologicalProcessOrActivity
type: Class
comment: Either an individual molecular activity, or a collection of causally connected molecular activities
subclass of: BiologicalEntity
is part of: schema.biothings.io

MolecularActivity
type: Class
comment: An execution of a molecular function carried out by a gene product or macromolecular complex.
subclass of: BiologicalProcessOrActivity
is part of: schema.biothings.io

ActivityAndBehavior
type: Class
comment: Activity or behavior of any independent integral living, organization or mechanical actor in the world
subclass of: Occurrent
is part of: schema.biothings.io

Procedure
type: Class
comment: A series of actions conducted in a certain order or manner
subclass of: Occurrent
is part of: schema.biothings.io

Phenomenon
type: Class
comment: a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question
subclass of: Occurrent
is part of: schema.biothings.io

BiologicalProcess
type: Class
comment: One or more causally connected executions of molecular functions
subclass of: BiologicalProcessOrActivity
is part of: schema.biothings.io

Pathway
type: Class
subclass of: BiologicalProcess
is part of: schema.biothings.io

Wikipathways
type: Class
subclass of: Pathway
is part of: schema.biothings.io

Reactome
type: Class
subclass of: Pathway
is part of: schema.biothings.io

PhysiologicalProcess
type: Class
subclass of: BiologicalProcess
is part of: schema.biothings.io

CellularComponent
type: Class
comment: A location in or around a cell
subclass of: AnatomicalEntity
is part of: schema.biothings.io

Cell
type: Class
subclass of: AnatomicalEntity
is part of: schema.biothings.io

CellLine
type: Class
subclass of: Biosample
is part of: schema.biothings.io

GrossAnatomicalStructure
type: Class
subclass of: AnatomicalEntity
is part of: schema.biothings.io

ProteinStructure
type: Class
subclass of: InformationContentEntity
is part of: schema.biothings.io

ensembl
type: Property
comment: Ensembl ID for gene, protein or transcript
domain includes: GeneOrGeneProduct
domain includes: Transcript
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

hgnc
type: Property
comment: HGNC ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

mgi
type: Property
comment: MGI ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

rgd
type: Property
comment: RGD ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

zfin
type: Property
comment: ZFIN ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

flybase
type: Property
comment: FlyBase ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

sgd
type: Property
comment: SGD ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

pombase
type: Property
comment: PomBase ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

dictybase
type: Property
comment: DictyBase ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

tair
type: Property
comment: TAIR ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

uberon
type: Property
comment: Uberon ID for anatomy
domain includes: AnatomicalEntity
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

cl
type: Property
comment: CL ID for anatomy
domain includes: AnatomicalEntity
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

fbbt
type: Property
comment: FBbt ID for anatomy
domain includes: AnatomicalEntity
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

inTaxon
type: Property
comment: connects a thing to a class representing a taxon
domain includes: Gene
is part of: schema.biothings.io
range includes: OrganismTaxon

entrez
type: Property
comment: Entrez ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

pharos
type: Property
comment: Pharos ID for gene
domain includes: Gene
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

pharmgkb
type: Property
comment: PharmGKB ID
domain includes: Gene
domain includes: Pathway
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

wikipathways
type: Property
comment: wikipathways ID
domain includes: Pathway
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

reactome
type: Property
comment: reactome ID
domain includes: Pathway
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

go
type: Property
comment: gene ontology ID
domain includes: BiologicalProcessOrActivity
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

symbol
type: Property
comment: gene symbol
domain includes: Gene
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

uniprot
type: Property
comment: Protein Uniprot ID
domain includes: Protein
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

refseq
type: Property
comment: Refseq ID for gene, protein or transcript
domain includes: GeneOrGeneProduct
domain includes: Transcript
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

omim
type: Property
comment: omim ID for gene, or disease
domain includes: Gene
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

orphanet
type: Property
comment: Orphanet ID for disease
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

umls
type: Property
comment: Refseq ID for gene, protein or transcript
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

snomed
type: Property
comment: snomed ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

mondo
type: Property
comment: mondo ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

doid
type: Property
comment: disease ontology ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

bfo
type: Property
comment: bfo ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

cohd
type: Property
comment: cohd ID
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

hp
type: Property
comment: hp ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

efo
type: Property
comment: EFO ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

kegg
type: Property
comment: kegg ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

meddra
type: Property
comment: meddra ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

medgen
type: Property
comment: medgen ID
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

mesh
type: Property
comment: mesh ID
domain includes: DiseaseOrPhenotypicFeature
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

unigene
type: Property
comment: unigene ID
domain includes: Gene
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

pdb
type: Property
comment: PDB ID
domain includes: ProteinStructure
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

dbsnp
type: Property
comment: dbsnp ID
domain includes: SequenceVariant
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

clinvar
type: Property
comment: clinvar Variant ID
domain includes: SequenceVariant
is part of: schema.biothings.io
range includes: Integer
sub property of: identifier

inchi
type: Property
comment: Inchi for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

inchikey
type: Property
comment: Inchikey for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

rxcui
type: Property
comment: RXCUI for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

smiles
type: Property
comment: Smiles for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

pubchem
type: Property
comment: PubChem ID for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

chembl
type: Property
comment: ChEMBL compound ID for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

drugbank
type: Property
comment: DrugBank ID for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

unii
type: Property
comment: UNII ID for chemical
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text
sub property of: identifier

molecularFormula
type: Property
comment: Chemical molecular formula
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: Text

interactingDrug
type: Property
comment: Another drug that is known to interact with this drug in a way that impacts the effect of this drug or causes a risk to the patient. Note: disease interactions are typically captured as contraindications.
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: ChemicalSubstance

metabolizedBy
type: Property
comment: Proteins that metabolize chemicals
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: GeneOrGeneProduct
inverse of: metabolize

metabolize
type: Property
comment: Proteins that metabolize chemicals
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: ChemicalSubstance
inverse of: metabolizedBy

target
type: Property
comment: Genes or Proteins that are targeted by chemicals
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: GeneOrGeneProduct
inverse of: targetedBy

targetedBy
type: Property
comment: Chemicals target genes or proteins
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: ChemicalSubstance
inverse of: target

enablesMF
type: Property
comment: GO molecular function enabled by the gene/protein.
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: MolecularActivity
inverse of: enabledBy

enabledBy
type: Property
comment: GO molecular function enabled by the gene/protein.
domain includes: MolecularActivity
is part of: schema.biothings.io
range includes: GeneOrGeneProduct
inverse of: enablesMF

involvedInBP
type: Property
comment: GO biological process this gene/protein is involved in.
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: BiologicalProcess
inverse of: bpHasParticipants

bpHasParticipants
type: Property
comment: GO biological process this gene/protein is involved in.
domain includes: BiologicalProcess
is part of: schema.biothings.io
range includes: GeneOrGeneProduct
inverse of: involvedInBP

involvedInCC
type: Property
comment: GO cellular component this gene/protein is involved in.
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: CellularComponent
inverse of: ccHasParticipants

ccHasParticipants
type: Property
comment: GO cellular component this gene/protein is involved in.
domain includes: CellularComponent
is part of: schema.biothings.io
range includes: GeneOrGeneProduct
inverse of: involvedInCC

involvedInPathway
type: Property
comment: An interaction between a biological entity and a pathway
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: Pathway
inverse of: pathwayHasParticipants

pathwayHasParticipants
type: Property
comment: An interaction between a biological entity and a pathway
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: Pathway
inverse of: involvedInPathway

involvedInWikipathways
type: Property
comment: An interaction between a biological entity and a wikipathway
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: Wikipathways
sub property of: involvedInPathway

involvedInReactome
type: Property
comment: An interaction between a biological entity and a reactome pathway
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: Reactome
sub property of: involvedInPathway

hasHomolog
type: Property
comment: Shared ancestry between protein or gene
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: GeneOrGeneProduct

orthologousTo
type: Property
comment: Orthologous to
domain includes: GeneOrGeneProduct
sub property of: hasHomolog
is part of: schema.biothings.io
range includes: GeneOrGeneProduct

treats
type: Property
comment: holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it is used to treat
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature
inverse of: treatedBy

causes
type: Property
comment: Specifying a cause of something in general. e.g in medicine , one of the causative agent(s) that are most directly responsible for the pathophysiologic process that eventually results in the occurrence.
domain includes: ChemicalSubstance
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature
inverse of: causedBy

causedBy
type: Property
comment: A condition caused by something
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: ChemicalSubstance
range includes: GeneOrGeneProduct
inverse of: causes

associatedWith
type: Property
comment: Has a relationship to
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity

hasChildren
type: Property
comment: is children of
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity
inverse of: hasParents

hasParents
type: Property
comment: is parents of
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity
inverse of: hasChildren

contraindication
type: Property
comment: holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it might cause side effect
domain includes: ChemicalSubstance
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature
inverse of: contraindicatedBy

contraindicatedBy
type: Property
comment: holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it might cause side effect
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: ChemicalSubstance
inverse of: contraindication

treatedBy
type: Property
comment: holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is used to treat the condition
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: ChemicalSubstance
inverse of: treats

variantAssociatedWithGene
type: Property
comment: holds between a variant and a gene
domain includes: SequenceVariant
is part of: schema.biothings.io
range includes: Gene
inverse of: geneAssociatedWithVariant

variantAssociatedWithCondition
type: Property
comment: holds between a variant and a condition
domain includes: SequenceVariant
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature
inverse of: conditionAssociatedWithVariant

conditionAssociatedWithVariant
type: Property
comment: holds between a variant and a condition
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: SequenceVariant
inverse of: variantAssociatedWithCondition

geneAssociatedWithVariant
type: Property
comment: holds between a gene and a variant.
domain includes: Gene
is part of: schema.biothings.io
range includes: SequenceVariant
inverse of: variantAssociatedWithGene

molecularlyInteractsWith
type: Property
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity

geneticallyInteractsWith
type: Property
comment: holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality.
domain includes: Gene
is part of: schema.biothings.io
range includes: Gene

affectsAbundanceOf
type: Property
comment: holds between two molecular entities where the action or effect of one changes the amount of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesAbundanceOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the amount of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity

decreasesAbundanceOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the amount of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity

affectsActivityOf
type: Property
comment: holds between two molecular entities where the action or effect of one changes the activity of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity

increasesActivityOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the activity of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity
inverse of: activityIncreasedBy

activityIncreasedBy
type: Property
comment: holds between two molecular entities where the action or effect of one is increased by the activity of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity
inverse of: increasesActivityOf

decreasesActivityOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the activity of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity
inverse of: activityDecreasedBy

activityDecreasedBy
type: Property
comment: holds between two molecular entities where the action or effect of one is decreased by the activity of the other within a system of interest
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: BiologicalEntity
inverse of: decreasesActivityOf

affectsExpressionOf
type: Property
comment: holds between two molecular entities where the action or effect of one changes the level of expression of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: GenomicEntity

increasesExpressionOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the level of expression of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: GenomicEntity

decreasesExpressionOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the level of expression of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: GenomicEntity

affectsFoldingOf
type: Property
comment: holds between two molecular entities where the action or effect of one changes the rate or quality of folding of the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesFoldingOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate or quality of folding of the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesFoldingOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate or quality of folding of the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsLocalizationOf
type: Property
comment: holds between two molecular entities where the action or effect of one changes the localization of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesLocalizationOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the proper localization of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesLocalizationOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the proper localization of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsMetabolicProcessingOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the metabolic processing of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesMetabolicProcessingOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate of metabolic processing of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesMetabolicProcessingOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate of metabolic processing of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsMolecularModificationOf
type: Property
comment: holds between two molecular entities where the action or effect of one leads changes in the molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesMolecularModificationOf
type: Property
comment: holds between two molecular entities where the action or effect of one leads to increased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesMolecularModificationOf
type: Property
comment: holds between two molecular entities where the action or effect of one leads to decreased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsSynthesisOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the rate of chemical synthesis of the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesSynthesisOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate of chemical synthesis of the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesSynthesisOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate of chemical synthesis of the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsDegradationOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the rate of degradation of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesDegradationOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate of degradation of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesDegradationOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate of degradation of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsMutationRateOf
type: Property
comment: holds between a molecular entity and a genomic entity where the action or effect of the molecular entity impacts the rate of mutation of the genomic entity within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: GenomicEntity

increasesMutationRateOf
type: Property
comment: holds between a molecular entity and a genomic entity where the action or effect of the molecular entity increases the rate of mutation of the genomic entity within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: GenomicEntity

decreasesMutationRateOf
type: Property
comment: holds between a molecular entity and a genomic entity where the action or effect of the molecular entity decreases the rate of mutation of the genomic entity within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: GenomicEntity

affectsResponseTo
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesResponseTo
type: Property
comment: holds between two molecular entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesResponseTo
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsSplicingOf
type: Property
comment: holds between a molecular entity and an mRNA where the action or effect of the molecular entity impacts the splicing of the mRNA
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: Transcript

increasesSplicingOf
type: Property
comment: holds between a molecular entity and an mRNA where the action or effect of the molecular entity increases the proper splicing of the mRNA
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: Transcript

decreasesSplicingOf
type: Property
comment: holds between a molecular entity and an mRNA where the action or effect of the molecular entity decreases the proper splicing of the mRNA
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: Transcript

affectsStabilityOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the stability of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesStabilityOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the stability of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesStabilityOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the stability of the other within a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsTransportOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the rate of transport of the other across some boundary in a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesTransportOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate of transport of the other across some boundary in a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesTransportOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate of transport of the other across some boundary in a system of interest
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsSecretionOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the rate of secretion of the other out of a cell, gland, or organ
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesSecretionOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate of secretion of the other out of a cell, gland, or organ
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesSecretionOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate of secretion of the other out of a cell, gland, or organ
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

affectsUptakeOf
type: Property
comment: holds between two molecular entities where the action or effect of one impacts the rate of uptake of the other into of a cell, gland, or organ
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

increasesUptakeOf
type: Property
comment: holds between two molecular entities where the action or effect of one increases the rate of uptake of the other into of a cell, gland, or organ
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

decreasesUptakeOf
type: Property
comment: holds between two molecular entities where the action or effect of one decreases the rate of uptake of the other into of a cell, gland, or organ
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

regulates,ProcessToProcess
type: Property
domain includes: Occurrent
is part of: schema.biothings.io
range includes: Occurrent

regulates,EntityToEntity
type: Property
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: MolecularEntity

hasGeneProduct
type: Property
comment: holds between a gene and a transcribed and/or translated product generated from it
domain includes: Gene
is part of: schema.biothings.io
range includes: GeneProduct
inverse of: isTranslatedFrom

isTranslatedFrom
type: Property
comment: holds between gene product and a gene
domain includes: GeneProduct
is part of: schema.biothings.io
range includes: Gene

hasTranscript
type: Property
comment: holds between a gene and a gene transcript
domain includes: Gene
is part of: schema.biothings.io
range includes: Transcript
inverse of: transcribedFrom

transcribedFrom
type: Property
comment: holds between a gene and a gene transcript
domain includes: Gene
is part of: schema.biothings.io
range includes: Transcript
inverse of: hasTranscript

hasProteinStructure
type: Property
comment: holds between a gene or gene product and a protein structure
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: ProteinStructure

inPathwayWith
type: Property
comment: holds between two genes or gene products that are part of in the same biological pathway
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: GeneOrGeneProduct

inComplexWith
type: Property
comment: holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: GeneOrGeneProduct

inCellPopulationWith
type: Property
comment: holds between two genes or gene products that are expressed in the same cell type or population
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: GeneOrGeneProduct

geneAssociatedWithCondition
type: Property
comment: holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with
domain includes: Gene
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature

correlatedWith
type: Property
comment: holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature.
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: MolecularEntity

hasBiomarker
type: Property
comment: holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature.
domain includes: DiseaseOrPhenotypicFeature
is part of: schema.biothings.io
range includes: MolecularEntity

biomarkerFor
type: Property
comment: holds between a measurable molecular entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature.
domain includes: MolecularEntity
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature

expressedIn
type: Property
comment: holds between a gene or gene product and an anatomical entity in which it is expressed
domain includes: GeneOrGeneProduct
is part of: schema.biothings.io
range includes: AnatomicalEntity

expresses
type: Property
comment: holds between an anatomical entity and gene or gene product that is expressed there
domain includes: AnatomicalEntity
is part of: schema.biothings.io
range includes: GeneOrGeneProduct

hasPhenotype
type: Property
comment: holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature).
domain includes: BiologicalEntity
is part of: schema.biothings.io
range includes: DiseaseOrPhenotypicFeature

precedes
type: Property
comment: holds between two processes, where one completes before the other begins
domain includes: Occurrent
is part of: schema.biothings.io
range includes: Occurrent

subclassOf
type: Property
comment: holds between two classes where the domain class is a specialization of the range class
domain includes: OntologyClass
is part of: schema.biothings.io
range includes: OntologyClass