| 1 | {"pathway":{"@context":["https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld"],"backgroundColor":"white","borderWidth":0,"color":"black","contains":["idf5d46ea5","id470cff36","id5f8928d9","id8bcbba03","id3be9044e","id1a1510f9","idc547796a","idc7e0d5ef","id43cd63bf","id5e1c090","id4c215f69","idd40ab9d9","idec31a51b","id9eaaace1","idef34bebb","idb38535b4","id9f3c866","ida293497b","id2b98bb7b","id21672e4c","id45855ca0","id7c2bea8f","id66f46233","id98d96a57","id9fa508f8","id2a1a0c7b","id1f4633b6","idf01f90f2","b5a59","ec34d","e054d","c8025","ac0b7","d163a","bbf43","f4db3","c5294","e6bd7","a402b","a3eae","a61ad","f9f28","c36be","a773b","c7b99","d6d88","eaf4e","ab86e","f4b20","c95c0","f7754","a3e69","ee0b6","ab2b3","ea1de","fd8e3","a59bc","e2e8a","bb21e","fe08c","c8b89","c1060","dd9c0","a11d5","d0ba6","d1f62","a9aac","ec6ad","c8ca2","bbca4","cf05a","d2a0d","bde8d","ffa37","f89bd","f4888","d29ee","fbdab"],"drawAs":"rect","gpmlElementName":"Pathway","height":946,"kaavioType":"Group","name":"Aging","padding":5,"type":["Pathway","http://identifiers.org/pw/PW:0000143","http://identifiers.org/pw/PW:0000651"],"width":956,"x":0,"y":0,"zIndex":0,"fontSize":12,"fontWeight":"bold","textAlign":"left","verticalAlign":"top","comments":[{"source":"WikiPathways-category","content":"Physiological Process"},{"source":"WikiPathways-description","content":"Aging in C. elegans involves measurable declines in morphology, reproduction, and behavior. Understanding the cellular and molecular processes leading to senescence in this nematode began in the early 1980s with the targeted identification of mutants that extended life span (an AGE phenotype). These studies identified at least two key regulators of life span, DAF-2, an insulin/IGF receptor ortholog, and DAF-16, a Forkhead-related transcription factor. Since then many more genes and pathways involved in senescence have been identified. Almost all of these genes play important roles in cellular and organismal-level processes other than aging, such as dauer formation, stress response, feeding, and chemosensation."}],"author":"kyook@caltech.edu","organism":"Caenorhabditis elegans","lastModified":"10/17/2013","standardName":"Aging","displayName":"Aging","textContent":"Name: Aging\nLast Modified: 10/17/2013\nOrganism: Caenorhabditis elegans","isSimilarTo":"http://wikipathways.org/index.php/Special:SearchPathways?query=Aging&species=Caenorhabditis%20elegans&doSearch=1","id":"hash://sha256/308b0a1d0e165600c9ca0153eca9f246f03a5695880d37f3bff20a17996d2ab6"},"entityMap":{"f4b20":{"textContent":"DAF-18/PTEN","id":"f4b20","wpType":"GeneProduct","comments":[{"content":"daf-18 functions upstream to akt-1 and akt-2"},{"content":"daf-18 acts downstream of age-1"}],"citations":["publicationXrefee0","publicationXrefe61"],"x":227,"y":235,"width":80,"height":20,"zIndex":32768,"backgroundColor":"#009900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"T07A9.6","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"b5a59":{"id":"b5a59","x":26.165159773734047,"y":90.17256637168143,"width":633.9926893020893,"height":63.5,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"ArcPathVisio","rotation":176.18592516570968,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"textRotation":-176.18592516570968,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"f4db3":{"textContent":"Insulin-like \nsignals","id":"f4db3","x":228,"y":32,"width":80,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"c95c0":{"textContent":"AGE-1/PI3K","id":"c95c0","wpType":"GeneProduct","comments":[{"content":"age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase catalytic subunit."}],"citations":["publicationXreff57"],"x":227,"y":152,"width":80,"height":20,"zIndex":32768,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"B0334.8","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ec34d":{"id":"ec34d","cellularComponent":"Nucleus","borderStyle":"double","x":199.5,"y":511.5,"width":432,"height":227,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","borderWidth":3,"color":"#c0c0c0","rotation":0,"textAlign":"center","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode","PhysicalEntity","CellularComponent","Nucleus"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"c5294":{"textContent":"Proteosome degradation\npathway","id":"c5294","x":361,"y":884,"width":127,"height":32,"zIndex":28672,"backgroundColor":"#ffffff","fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"f7754":{"textContent":"PIP2","id":"f7754","wpType":"Metabolite","x":197,"y":189,"width":44,"height":19,"zIndex":32768,"fontSize":10,"verticalAlign":"middle","drawAs":"none","color":"#0000ff","textAlign":"center","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"ChEBI","dbId":"18348","type":["DataNode","SingleFreeNode","Metabolite"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"e054d":{"id":"e054d","x":684,"y":12.5,"width":240,"height":399.5,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"rect","rotation":0,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"e6bd7":{"textContent":"KEY","id":"e6bd7","x":675,"y":16,"width":80,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"e9b6a":{"textContent":"14-3-3","id":"e9b6a","wpType":"GeneProduct","x":12,"y":48,"width":80,"height":20,"zIndex":32768,"fontSize":10,"verticalAlign":"middle","textAlign":"center","color":"#000000","backgroundColor":"#ffffff","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"drawAs":"rect","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"F52D10.3","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"a3e69"},"c8025":{"textContent":"P","id":"c8025","cellularComponent":"Vesicle","x":705,"y":170,"width":16,"height":16,"zIndex":16384,"backgroundColor":"#ffcc33","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode","PhysicalEntity","CellularComponent","Vesicle"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"a402b":{"textContent":"Blocks action, inhibits","id":"a402b","x":734,"y":46,"width":152,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"ee0b6":{"textContent":"DAF-2/InR","id":"ee0b6","wpType":"GeneProduct","comments":[{"content":"insulin/IGF-1 pathway can diverge to regulate the timing of reproduction independently of longevity (Dillin et al., 2002a)."}],"citations":["publicationXrefeef"],"x":228,"y":86,"width":80,"height":20,"zIndex":32769,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"Y55D5A.5","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ac0b7":{"textContent":"Reproductive\nlongevity","id":"ac0b7","x":397,"y":102,"width":93,"height":43,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","rotation":0,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"a3eae":{"textContent":"Activates through modification","id":"a3eae","x":733,"y":68,"width":152,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"ab2b3":{"textContent":"PIP3","id":"ab2b3","wpType":"Metabolite","x":289,"y":189,"width":42,"height":19,"zIndex":32770,"fontSize":10,"verticalAlign":"middle","drawAs":"none","color":"#0000ff","textAlign":"center","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"ChEBI","dbId":"16618","type":["DataNode","SingleFreeNode","Metabolite"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"d163a":{"textContent":"Oxidative stress\nresponse","id":"d163a","x":486,"y":576,"width":96,"height":40,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","rotation":0,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"a61ad":{"textContent":"Binds to","id":"a61ad","x":732,"y":86,"width":55,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"fd8e3":{"textContent":"PDK-1/PKD1","id":"fd8e3","wpType":"GeneProduct","comments":[{}],"citations":["publicationXrefd91"],"x":168,"y":335,"width":80,"height":20,"zIndex":32772,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"H42K12.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"bbf43":{"id":"bbf43","x":695,"y":302,"width":78,"height":28,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","rotation":0,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"f9f28":{"textContent":"Phosphorylated","id":"f9f28","x":726,"y":167,"width":80,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"be992":{"textContent":"AKT-1/Akt/PKB","id":"be992","wpType":"GeneProduct","comments":[{}],"citations":["publicationXrefd91","publicationXrefa81"],"x":8,"y":8,"width":80,"height":20,"zIndex":32773,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"C12D8.10","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"a59bc"},"c8ca2":{"textContent":"Me","id":"c8ca2","cellularComponent":"Vesicle","x":705,"y":200,"width":16,"height":16,"zIndex":32791,"backgroundColor":"#0066ff","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode","PhysicalEntity","CellularComponent","Vesicle"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"c36be":{"textContent":"Longevity promoting action","id":"c36be","x":782,"y":236,"width":144,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"a64c1":{"textContent":"AKT-2/Akt/PKB","id":"a64c1","wpType":"GeneProduct","comments":[{}],"citations":["publicationXrefd91","publicationXrefa81"],"x":92,"y":8,"width":80,"height":20,"zIndex":32774,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"F28H6.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"a59bc"},"bde8d":{"textContent":"Dauer\ndevelopment","id":"bde8d","x":389,"y":150,"width":93,"height":43,"zIndex":32796,"fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","rotation":0,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"a773b":{"textContent":"Longevity reducing action","id":"a773b","x":783,"y":267,"width":123,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"fc419":{"textContent":"DAF-16/FOXO","id":"fc419","wpType":"GeneProduct","comments":[{"content":"PRMT-1 specifically methylates the C terminus of the forkhead domain (FH-C) in DAF-16 blocking binding to 14-3-3 protein."},{"content":"DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases."},{"content":"T242 is an AKT-mediated phosphorylation site in DAF-16"}],"citations":["publicationXrefa47","publicationXrefb69","publicationXrefed9","publicationXrefa81"],"x":12,"y":12,"width":80,"height":20,"zIndex":32776,"backgroundColor":"#339900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","borderRadius":15,"color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"R13H8.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","burrs":["b2dc4"],"isPartOf":"a3e69"},"f89bd":{"textContent":"Innate immunity","id":"f89bd","x":487,"y":615,"width":96,"height":40,"zIndex":32798,"backgroundColor":"#ffffff","fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","rotation":0,"textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"c7b99":{"textContent":"Activates in general","id":"c7b99","x":732,"y":104,"width":111,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"e2e8a":{"textContent":"JNK-1","id":"e2e8a","wpType":"GeneProduct","comments":[{"content":"DAF-16 binds to JNK-1."},{"content":"JNK-1 binds and phosphorylates DAF-16."}],"citations":["publicationXreff8b"],"x":152,"y":440,"width":80,"height":20,"zIndex":32777,"backgroundColor":"#009900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"B0478.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","burrs":["d1419"]},"f4888":{"textContent":"DNA damage\nrepair","id":"f4888","x":487,"y":654,"width":96,"height":40,"zIndex":32799,"fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","rotation":0,"textAlign":"center","color":"#000000","backgroundColor":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"d6d88":{"textContent":"Translocates","id":"d6d88","x":732,"y":125,"width":80,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"bb21e":{"textContent":"DAF-16/FOXO","id":"bb21e","wpType":"GeneProduct","citations":["publicationXrefa47","publicationXrefb69","publicationXreff8b"],"x":367,"y":603,"width":80,"height":20,"zIndex":32778,"backgroundColor":"#339900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","borderRadius":15,"color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"R13H8.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","burrs":["e953c","de55b"]},"eaf4e":{"textContent":"Converts to","id":"eaf4e","x":733,"y":141,"width":80,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"fe08c":{"textContent":"JKK-1","id":"fe08c","wpType":"GeneProduct","citations":["publicationXreff8b"],"x":76,"y":395,"width":80,"height":20,"zIndex":32780,"backgroundColor":"#009900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"F35C8.3","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ab86e":{"textContent":"Process","id":"ab86e","x":784,"y":307,"width":80,"height":20,"zIndex":28672,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"c1060":{"textContent":"PRMT-1","id":"c1060","wpType":"GeneProduct","comments":[{}],"citations":["publicationXrefed9"],"x":298,"y":397,"width":80,"height":20,"zIndex":32783,"backgroundColor":"#009900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"Y113G7B.17","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"bbca4":{"textContent":"Methylated","id":"bbca4","x":715,"y":197,"width":80,"height":20,"zIndex":32792,"backgroundColor":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"center","color":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","borderWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"dd9c0":{"textContent":"DAF-16/FOXO","id":"dd9c0","wpType":"GeneProduct","comments":[{"content":"DAF-16 bound directly to PRMT-1 in in vitro pulldown assays , HA-PRMT-1 was coimmunoprecipitated with FLAG-DAF-16 only when the both proteins were\ncoexpressed."},{}],"citations":["publicationXrefed9"],"x":193,"y":473,"width":80,"height":20,"zIndex":32784,"backgroundColor":"#339900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","borderRadius":15,"color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"R13H8.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","burrs":["e3bc3","cb977"]},"a11d5":{"textContent":"DAF-16/FOXO","id":"a11d5","wpType":"GeneProduct","citations":["publicationXrefee4"],"x":325.00000000000006,"y":811,"width":80,"height":20,"zIndex":32785,"backgroundColor":"#339900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","borderRadius":15,"color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"R13H8.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"d0ba6":{"textContent":"RLE-1","id":"d0ba6","wpType":"GeneProduct","comments":[{"content":"age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase catalytic subunit."},{"content":"RLE-1 physically interacts with DAF-16. RLE-1 C terminus is required for the interaction of RLE-1 with DAF-16."}],"citations":["publicationXrefee4"],"x":305,"y":772,"width":80,"height":20,"zIndex":32786,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"M142.6","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"d1f62":{"textContent":"SMK-1","id":"d1f62","wpType":"GeneProduct","comments":[{"content":"SMK-1 was temporally and spatially colocalized with active DAF-16."},{"content":"smk-1 RNAi does not cause a general sickness in long-lived animals but rather specifically affects IIS-regulated life span."},{"content":"DAF-16 and SMK-1 do not directly or indirectly regulate expression or localization of one another."},{"content":"SMK-1 specifies the longevity function of DAF-16 by\naffecting the efficiency of transcription of DAF-16 target genes involved in oxidative and UV stress response and innate immunity but is not required for DAF-16 regulation of heat-stress-response genes."}],"citations":["publicationXrefe0e"],"x":402,"y":567,"width":80,"height":20,"zIndex":32787,"backgroundColor":"#009900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"F41E6.4","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"a9aac":{"textContent":"SGK-1","id":"a9aac","wpType":"GeneProduct","comments":[{"content":"DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases."}],"x":517,"y":333,"width":80,"height":20,"zIndex":32788,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"W10G6.2","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ec6ad":{"textContent":"daf-15","id":"ec6ad","wpType":"GeneProduct","comments":[{"content":"Reduced smk-1 resulted in increased expression of daf-15 mRNA, suggesting that SMK-1 is required for\nthe transcriptional repressor activity of DAF-16"}],"citations":["publicationXrefe0e"],"x":242,"y":630,"width":80,"height":20,"zIndex":32789,"backgroundColor":"#330033","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"drawAs":"rect","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"C10C5.6","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"cf05a":{"id":"cf05a","x":694,"y":236,"width":80,"height":20,"zIndex":32793,"backgroundColor":"#009900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"wpType":"Unknown","type":["DataNode","SingleFreeNode","Unknown"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"d2a0d":{"id":"d2a0d","x":694,"y":269,"width":80,"height":20,"zIndex":32794,"backgroundColor":"#ff6666","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"wpType":"Unknown","type":["DataNode","SingleFreeNode","Unknown"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"d29ee":{"textContent":"DAF-16/FOXO","id":"d29ee","wpType":"GeneProduct","comments":[{"content":"PRMT-1 specifically methylates the C terminus of the forkhead domain (FH-C) in DAF-16 blocking binding to 14-3-3 protein."},{"content":"DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases."},{"content":"T242 is an AKT-mediated phosphorylation site in DAF-16"}],"citations":["publicationXrefa47","publicationXrefb69","publicationXrefed9","publicationXrefa81"],"x":368,"y":440,"width":80,"height":20,"zIndex":32800,"backgroundColor":"#339900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","borderRadius":15,"color":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","borderWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"dbConventionalName":"WormBase","dbId":"R13H8.1","type":["DataNode","SingleFreeNode","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"publicationXrefe61":{"id":"publicationXrefe61","dbId":"7789761","dbConventionalName":"PubMed","standardName":"Genes that regulate both development and longevity in Caenorhabditis elegans.","source":"Genetics","year":1995,"authors":["Larsen PL","Albert PS","Riddle DL"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"1"},"publicationXreff57":{"id":"publicationXreff57","dbId":"8700226","dbConventionalName":"PubMed","standardName":"A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.","source":"Nature","year":1996,"authors":["Morris JZ","Tissenbaum HA","Ruvkun G"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"2"},"publicationXrefeef":{"id":"publicationXrefeef","dbId":"9252323","dbConventionalName":"PubMed","standardName":"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.","source":"Science","year":1997,"authors":["Kimura KD","Tissenbaum HA","Liu Y","Ruvkun G"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"3"},"publicationXrefa47":{"id":"publicationXrefa47","dbId":"9353126","dbConventionalName":"PubMed","standardName":"The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.","source":"Nature","year":1997,"authors":["Ogg S","Paradis S","Gottlieb S","Patterson GI","Lee L","Tissenbaum HA","Ruvkun G"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"4"},"publicationXrefb69":{"id":"publicationXrefb69","dbId":"9360933","dbConventionalName":"PubMed","standardName":"daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.","source":"Science","year":1997,"authors":["Lin K","Dorman JB","Rodan A","Kenyon C"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"5"},"publicationXrefee0":{"id":"publicationXrefee0","dbId":"9885576","dbConventionalName":"PubMed","standardName":"The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.","source":"Mol Cell","year":1998,"authors":["Ogg S","Ruvkun G"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"6"},"publicationXrefa81":{"id":"publicationXrefa81","dbId":"9716402","dbConventionalName":"PubMed","standardName":"Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.","source":"Genes Dev","year":1998,"authors":["Paradis S","Ruvkun G"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"7"},"publicationXrefd91":{"id":"publicationXrefd91","dbId":"10364160","dbConventionalName":"PubMed","standardName":"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.","source":"Genes Dev","year":1999,"authors":["Paradis S","Ailion M","Toker A","Thomas JH","Ruvkun G"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"8"},"publicationXreffa0":{"id":"publicationXreffa0","dbId":"12399591","dbConventionalName":"PubMed","standardName":"Timing requirements for insulin/IGF-1 signaling in C. elegans.","source":"Science","year":2002,"authors":["Dillin A","Crawford DK","Kenyon C"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"9"},"publicationXreff8b":{"id":"publicationXreff8b","dbId":"15767565","dbConventionalName":"PubMed","standardName":"JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.","source":"Proc Natl Acad Sci U S A","year":2005,"authors":["Oh SW","Mukhopadhyay A","Svrzikapa N","Jiang F","Davis RJ","Tissenbaum HA"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"10"},"publicationXrefe0e":{"id":"publicationXrefe0e","dbId":"16530049","dbConventionalName":"PubMed","standardName":"SMK-1, an essential regulator of DAF-16-mediated longevity.","source":"Cell","year":2006,"authors":["Wolff S","Ma H","Burch D","Maciel GA","Hunter T","Dillin A"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"11"},"publicationXrefee4":{"id":"publicationXrefee4","dbId":"17276341","dbConventionalName":"PubMed","standardName":"RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.","source":"Dev Cell","year":2007,"authors":["Li W","Gao B","Lee SM","Bennett K","Fang D"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"12"},"publicationXrefd3a":{"id":"publicationXrefd3a","dbId":"21937765","dbConventionalName":"PubMed","standardName":"Longevity and stress in Caenorhabditis elegans.","source":"Aging (Albany NY)","year":2011,"authors":["Zhou KI","Pincus Z","Slack FJ"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"13"},"publicationXrefed9":{"id":"publicationXrefed9","dbId":"21531333","dbConventionalName":"PubMed","standardName":"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.","source":"Cell Metab","year":2011,"authors":["Takahashi Y","Daitoku H","Hirota K","Tamiya H","Yokoyama A","Kako K","Nagashima Y","Nakamura A","Shimada T","Watanabe S","Yamagata K","Yasuda K","Ishii N","Fukamizu A"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"14"},"publicationXrefc18":{"id":"publicationXrefc18","dbId":"22939742","dbConventionalName":"PubMed","standardName":"Lessons from C. elegans: signaling pathways for longevity.","source":"Trends Endocrinol Metab","year":2012,"authors":["Lapierre LR","Hansen M"],"type":["PublicationXref"],"gpmlElementName":"PublicationXref","textContent":"15"},"http://identifiers.org/pw/PW:0000143":{"term":"insulin signaling pathway","dbId":"PW:0000143","ontology":"Pathway Ontology","type":["openControlledVocabulary"],"gpmlElementName":"openControlledVocabulary","id":"http://identifiers.org/pw/PW:0000143"},"http://identifiers.org/pw/PW:0000651":{"term":"aging pathway","dbId":"PW:0000651","ontology":"Pathway Ontology","type":["openControlledVocabulary"],"gpmlElementName":"openControlledVocabulary","id":"http://identifiers.org/pw/PW:0000651"},"b2dc4":{"isAttachedTo":"fc419","textContent":"P","id":"b2dc4","comments":[{"content":"T242 Phosphorylation"}],"attachmentDisplay":{"position":[1,1],"offset":[0,0]},"width":15,"height":15,"backgroundColor":"#ffcc00","drawAs":"Ellipse","color":"#000000","borderWidth":1,"textAlign":"center","padding":1,"fontSize":10,"verticalAlign":"middle","stateType":"Unknown","type":["State","Burr"],"kaavioType":"Burr","gpmlElementName":"State"},"d1419":{"isAttachedTo":"e2e8a","textContent":"P","id":"d1419","attachmentDisplay":{"position":[0.03749999999999998,1],"offset":[0,0]},"width":15,"height":15,"backgroundColor":"#ffcc00","drawAs":"Ellipse","color":"#000000","borderWidth":1,"textAlign":"center","padding":1,"fontSize":10,"verticalAlign":"middle","stateType":"Unknown","type":["State","Burr"],"kaavioType":"Burr","gpmlElementName":"State"},"e953c":{"isAttachedTo":"bb21e","textContent":"P","id":"e953c","attachmentDisplay":{"position":[0,0.95],"offset":[0,0]},"width":15,"height":15,"backgroundColor":"#ffcc00","drawAs":"Ellipse","color":"#000000","borderWidth":1,"textAlign":"center","padding":1,"fontSize":10,"verticalAlign":"middle","stateType":"Unknown","type":["State","Burr"],"kaavioType":"Burr","gpmlElementName":"State"},"de55b":{"isAttachedTo":"bb21e","textContent":"Me","id":"de55b","attachmentDisplay":{"position":[1,1],"offset":[0,0]},"width":15,"height":15,"backgroundColor":"#0066cc","drawAs":"Ellipse","color":"#000000","borderWidth":1,"textAlign":"center","padding":1,"fontSize":10,"verticalAlign":"middle","stateType":"Unknown","type":["State","Burr"],"kaavioType":"Burr","gpmlElementName":"State"},"e3bc3":{"isAttachedTo":"dd9c0","textContent":"Me","id":"e3bc3","attachmentDisplay":{"position":[0.9625,1],"offset":[0,0]},"width":15,"height":15,"backgroundColor":"#0066cc","drawAs":"Ellipse","color":"#000000","borderWidth":1,"textAlign":"center","padding":1,"fontSize":10,"verticalAlign":"middle","stateType":"Unknown","type":["State","Burr"],"kaavioType":"Burr","gpmlElementName":"State"},"cb977":{"isAttachedTo":"dd9c0","textContent":"P","id":"cb977","comments":[{"content":"JNK-1 binds and phosphorylates DAF-16"}],"attachmentDisplay":{"position":[0.0625,1],"offset":[0,0]},"width":15,"height":15,"backgroundColor":"#ffcc33","drawAs":"Ellipse","color":"#000000","borderWidth":1,"textAlign":"center","padding":1,"fontSize":10,"verticalAlign":"middle","stateType":"Unknown","type":["State","Burr"],"kaavioType":"Burr","gpmlElementName":"State"},"idf5d46ea5":{"id":"idf5d46ea5","citations":["publicationXrefee0"],"zIndex":12288,"borderWidth":1,"points":[{"x":299.5,"y":208,"isAttachedTo":"ab2b3","attachmentDisplay":{"position":[0.25,1],"offset":[0,0]},"orientation":[0,1]},{"x":230,"y":208,"isAttachedTo":"f7754","attachmentDisplay":{"position":[0.75,1],"offset":[0,0]},"orientation":[0,-1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge","SBO:0000167","SBO:0000393","SBO:0000394","DirectedInteraction"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"Arrow","isAttachedTo":["ab2b3","f7754"],"burrs":["e3f96"]},"e3f96":{"attachmentDisplay":{"position":[0.46871129788625526,0],"offset":[0,0]},"drawAs":"none","id":"e3f96","isAttachedTo":"idf5d46ea5","borderWidth":0,"height":0,"width":0,"zIndex":12288,"type":["Anchor","Burr"],"kaavioType":"Burr","gpmlElementName":"Anchor"},"id470cff36":{"id":"id470cff36","drawAs":"ElbowLine","zIndex":12288,"borderWidth":1,"points":[{"x":345.6108041743401,"y":640.8839779005525,"orientation":[-1,0]},{"x":346.22467771639043,"y":631.3689379987723},{"x":324.1252302025783,"y":621.853898096992,"orientation":[-1,0]}],"color":"#000000","backgroundColor":"none","type":["GraphicalLine","Edge","SBO:0000169","Inhibition"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"TBar"},"id5f8928d9":{"id":"id5f8928d9","comments":[{"content":"AGE-1 works in a parallel pathway downstream of daf-2 signaling."}],"citations":["publicationXrefd91"],"zIndex":12288,"borderWidth":1,"points":[{"x":268,"y":106,"isAttachedTo":"ee0b6","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":267,"y":152,"isAttachedTo":"c95c0","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimStimulation","isAttachedTo":["ee0b6","c95c0"]},"id8bcbba03":{"id":"id8bcbba03","zIndex":12288,"borderWidth":1,"points":[{"x":219.53327571305098,"y":641.3137424373379},{"x":616.2489196197062,"y":641.3137424373379}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine"},"id3be9044e":{"id":"id3be9044e","citations":["publicationXrefd91"],"zIndex":12288,"borderWidth":1,"points":[{"x":208,"y":208,"isAttachedTo":"f7754","attachmentDisplay":{"position":[0.25,1],"offset":[0,0]},"orientation":[0,1]},{"x":208,"y":335,"isAttachedTo":"fd8e3","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","dbConventionalName":"WormBase","dbId":"WBInteraction000518714","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimStimulation","isAttachedTo":["f7754","fd8e3"]},"id1a1510f9":{"id":"id1a1510f9","zIndex":12288,"borderWidth":1,"points":[{"x":699.8556998556998,"y":54.35305435305435},{"x":729.1967291967292,"y":54.35305435305435}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge","SBO:0000169","Inhibition"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"TBar"},"id2a1a0c7b":{"id":"id2a1a0c7b","comments":[{"content":"an activating mutation in akt-1 or increased dosage of akt-1(+) can bypass the normal requirement for AGE-1 PI3K signaling but still partially depends on DAF-2 signaling,\nshowing that akt-1 is the major output of PI3K signaling but not the only output of the DAF-2 insulinlike receptor"}],"citations":["publicationXrefa81"],"zIndex":12288,"borderWidth":1,"points":[{"x":320.5,"y":208,"isAttachedTo":"ab2b3","attachmentDisplay":{"position":[0.75,1],"offset":[0,0]},"orientation":[0,1]},{"x":406,"y":326,"isAttachedTo":"a59bc","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimStimulation","isAttachedTo":["ab2b3","a59bc"]},"idc547796a":{"id":"idc547796a","zIndex":12288,"borderWidth":1,"points":[{"x":700.3367003367002,"y":75.51707551707551},{"x":726.3107263107263,"y":75.51707551707551}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"MimBinding"},"id1f4633b6":{"id":"id1f4633b6","citations":["publicationXrefd91"],"zIndex":12288,"borderWidth":1,"points":[{"x":248,"y":345,"isAttachedTo":"fd8e3","attachmentDisplay":{"position":[1,0.5],"offset":[0,0]},"orientation":[1,0]},{"x":316,"y":344,"isAttachedTo":"a59bc","attachmentDisplay":{"position":[0,0.5],"offset":[0,0]},"orientation":[1,0]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","dbConventionalName":"WormBase","dbId":"WBInteraction000518714","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimStimulation","isAttachedTo":["fd8e3","a59bc"]},"idc7e0d5ef":{"id":"idc7e0d5ef","zIndex":12288,"borderWidth":1,"points":[{"x":701.2987012987012,"y":96.71909571909572},{"x":727.2727272727273,"y":96.71909571909572}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine"},"id43cd63bf":{"id":"id43cd63bf","citations":["publicationXrefa81","publicationXrefed9"],"zIndex":12288,"borderWidth":2,"color":"#009933","points":[{"x":570,"y":452,"isAttachedTo":"fc419","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":570,"y":468,"isAttachedTo":"e9b6a","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","isAttachedTo":["fc419","e9b6a"]},"id5e1c090":{"id":"id5e1c090","zIndex":12288,"borderWidth":1,"points":[{"x":702.2607022607021,"y":114.47811447811446},{"x":728.2347282347282,"y":114.47811447811446}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"MimStimulation"},"id4c215f69":{"id":"id4c215f69","comments":[{"content":"JKK-1 is the upstream kinase of JNK-1 and phosphorylation of JNK-1 is required for lifespan extension."}],"citations":["publicationXreff8b"],"zIndex":12288,"borderWidth":1,"points":[{"x":116,"y":415,"isAttachedTo":"fe08c","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":172,"y":440,"isAttachedTo":"e2e8a","attachmentDisplay":{"position":[0.25,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimModification","isAttachedTo":["fe08c","e2e8a"]},"idd40ab9d9":{"id":"idd40ab9d9","zIndex":12288,"borderWidth":1,"points":[{"x":698.8034188034188,"y":153.16239316239316},{"x":728.3554741181858,"y":153.45854328905173}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"MimConversion"},"idf01f90f2":{"id":"idf01f90f2","comments":[{"content":"AKT phosphorylates DAF-16 at site T242, promoting its binding to 14-3-3."}],"citations":["publicationXrefed9"],"zIndex":12288,"borderWidth":1,"points":[{"x":406,"y":362,"isAttachedTo":"a59bc","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":493.54831733627856,"y":445.5562617232899,"isAttachedTo":"b7101","attachmentDisplay":{"position":[0.5554672845887629,0],"offset":[],"relativeOffset":[0,0]},"orientation":[]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","dbConventionalName":"WormBase","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimModification","isAttachedTo":["a59bc","id7c2bea8f"]},"idec31a51b":{"id":"idec31a51b","zIndex":12288,"strokeDasharray":"5,3","borderWidth":1,"points":[{"x":698.6496090973704,"y":135.74982231698652},{"x":729.2110874200421,"y":135.7498223169865}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["GraphicalLine","Edge"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"MimConversion"},"id98d96a57":{"id":"id98d96a57","comments":[{"content":"PRMT-1 methylates DAF-16, thereby blocking its phosphorylation by AKT."},{"content":"PRMT-1 blocks AKT-mediated phosphorylation of DAF-16 at T242 and thereby inhibits its 14-3-3 binding and cytoplasmic retention in C. elegans."},{"content":"PRMT-1 upregulates DAF-16 activity by inhibiting AKT-mediated phosphorylation of DAF-16 at T242."}],"citations":["publicationXrefed9"],"zIndex":12288,"borderWidth":1,"points":[{"x":338,"y":417,"isAttachedTo":"c1060","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":330,"y":463.2,"isAttachedTo":"b68c2","attachmentDisplay":{"position":[0.4,0],"offset":[],"relativeOffset":[0,0]},"orientation":[]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimModification","isAttachedTo":["c1060","id66f46233"]},"fbdab":{"id":"fbdab","drawAs":"ElbowLine","zIndex":32801,"borderWidth":1,"points":[{"x":463.78708551483425,"y":640.9249563699826,"orientation":[-1,0]},{"x":463.91082442252497,"y":636.8856383581515},{"x":463.91082442252497,"y":632.8463203463203},{"x":463.91082442252497,"y":628.884793076782},{"x":484.16865131018614,"y":624.9232658072438,"orientation":[-1,0]}],"color":"#000000","backgroundColor":"none","type":["GraphicalLine","Edge","SBO:0000167","SBO:0000393","SBO:0000394","DirectedInteraction"],"kaavioType":"Edge","gpmlElementName":"GraphicalLine","markerEnd":"Arrow"},"id9eaaace1":{"id":"id9eaaace1","comments":[{"content":"PRMT-1 phosphorylated DAF-16 translocates to the nucleus."},{"content":"JNK-1 phosphorylates DAF-16 leading to its translocation to the nucleus."}],"citations":["publicationXrefed9","publicationXreff8b"],"zIndex":12288,"strokeDasharray":"5,3","borderWidth":1,"color":"#9999ff","points":[{"x":233,"y":493,"isAttachedTo":"dd9c0","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":407,"y":603,"isAttachedTo":"bb21e","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge","SBO:0000167","SBO:0000393","SBO:0000394","DirectedInteraction"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"Arrow","isAttachedTo":["dd9c0","bb21e"]},"idef34bebb":{"id":"idef34bebb","zIndex":12288,"strokeDasharray":"5,3","borderWidth":1,"color":"#9999ff","points":[{"x":407,"y":623,"isAttachedTo":"bb21e","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":385.00000000000006,"y":811,"isAttachedTo":"a11d5","attachmentDisplay":{"position":[0.75,0],"offset":[0,0]},"orientation":[0,1]}],"drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge","SBO:0000167","SBO:0000393","SBO:0000394","DirectedInteraction"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"Arrow","isAttachedTo":["bb21e","a11d5"]},"idb38535b4":{"id":"idb38535b4","comments":[{"content":"RLE-1 regulates the cytoplasmic sequestration of DAF-16."}],"citations":["publicationXrefee4"],"zIndex":12288,"borderWidth":1,"points":[{"x":365.00000000000006,"y":831,"isAttachedTo":"a11d5","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":424.5,"y":884,"isAttachedTo":"c5294","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge","SBO:0000167","SBO:0000393","SBO:0000394","DirectedInteraction"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"Arrow","isAttachedTo":["a11d5","c5294"]},"id9f3c866":{"id":"id9f3c866","zIndex":12288,"borderWidth":1,"points":[{"x":268,"y":52,"isAttachedTo":"f4db3","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":268,"y":86,"isAttachedTo":"ee0b6","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimStimulation","isAttachedTo":["f4db3","ee0b6"]},"ida293497b":{"id":"ida293497b","comments":[{"content":"RLE-1 physically interacts with DAF-16. RLE-1 C terminus is required for the interaction of RLE-1 with DAF-16."}],"citations":["publicationXrefee4"],"zIndex":12288,"borderWidth":2,"color":"#339900","points":[{"x":365,"y":792,"isAttachedTo":"d0ba6","attachmentDisplay":{"position":[0.75,1],"offset":[0,0]},"orientation":[0,1]},{"x":365.00000000000006,"y":811,"isAttachedTo":"a11d5","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","isAttachedTo":["d0ba6","a11d5"]},"id2b98bb7b":{"id":"id2b98bb7b","zIndex":12288,"borderWidth":1,"points":[{"x":557,"y":353,"isAttachedTo":"a9aac","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":570,"y":432,"isAttachedTo":"fc419","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimModification","isAttachedTo":["a9aac","fc419"]},"id21672e4c":{"id":"id21672e4c","comments":[{"content":"insulin/IGF-1 pathway can diverge to regulate the timing of reproduction independently of longevity (Dillin et al., 2002a)."}],"citations":["publicationXrefe0e","publicationXreffa0"],"zIndex":12288,"borderWidth":1,"points":[{"x":288,"y":106,"isAttachedTo":"ee0b6","attachmentDisplay":{"position":[0.75,1],"offset":[0,0]},"orientation":[0,1]},{"x":397,"y":123.5,"isAttachedTo":"ac0b7","attachmentDisplay":{"position":[0,0.5],"offset":[0,0]},"orientation":[1,0]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimInhibition","isAttachedTo":["ee0b6","ac0b7"]},"id9fa508f8":{"id":"id9fa508f8","zIndex":12288,"borderWidth":1,"points":[{"x":267,"y":172,"isAttachedTo":"c95c0","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":266.92456479690526,"y":189,"isAttachedTo":"c531f","attachmentDisplay":{"position":[0.5312887021137447,0],"offset":[],"relativeOffset":[0,0]},"orientation":[]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimCatalysis","isAttachedTo":["c95c0","ea1de"]},"id45855ca0":{"id":"id45855ca0","zIndex":12288,"borderWidth":1,"points":[{"x":267,"y":235,"isAttachedTo":"f4b20","attachmentDisplay":{"position":[0.5,0],"offset":[0,0]},"orientation":[0,-1]},{"x":266.92456479690526,"y":208,"isAttachedTo":"e3f96","attachmentDisplay":{"position":[0.46871129788625526,0],"offset":[],"relativeOffset":[0,0]},"orientation":[]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimCatalysis","isAttachedTo":["f4b20","idf5d46ea5"]},"id7c2bea8f":{"id":"id7c2bea8f","zIndex":12288,"borderWidth":1,"points":[{"x":448,"y":450,"isAttachedTo":"d29ee","attachmentDisplay":{"position":[1,0.5],"offset":[0,0]},"orientation":[1,0]},{"x":530,"y":442,"isAttachedTo":"fc419","attachmentDisplay":{"position":[0,0.5],"offset":[0,0]},"orientation":[1,0]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimConversion","isAttachedTo":["d29ee","fc419"],"burrs":["b7101"]},"b7101":{"attachmentDisplay":{"position":[0.5554672845887629,0],"offset":[0,0]},"drawAs":"none","id":"b7101","isAttachedTo":"id7c2bea8f","borderWidth":0,"height":0,"width":0,"zIndex":12288,"type":["Anchor","Burr"],"kaavioType":"Burr","gpmlElementName":"Anchor"},"id66f46233":{"id":"id66f46233","zIndex":12288,"borderWidth":1,"points":[{"x":368,"y":450,"isAttachedTo":"d29ee","attachmentDisplay":{"position":[0,0.5],"offset":[0,0]},"orientation":[-1,0]},{"x":273,"y":483,"isAttachedTo":"dd9c0","attachmentDisplay":{"position":[1,0.5],"offset":[0,0]},"orientation":[-1,0]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimConversion","isAttachedTo":["d29ee","dd9c0"],"burrs":["b68c2"]},"b68c2":{"attachmentDisplay":{"position":[0.4,0],"offset":[0,0]},"drawAs":"none","id":"b68c2","isAttachedTo":"id66f46233","borderWidth":0,"height":0,"width":0,"zIndex":12288,"type":["Anchor","Burr"],"kaavioType":"Burr","gpmlElementName":"Anchor"},"ea1de":{"id":"ea1de","zIndex":32771,"borderWidth":1,"points":[{"x":230,"y":189,"isAttachedTo":"f7754","attachmentDisplay":{"position":[0.75,0],"offset":[0,0]},"orientation":[0,-1]},{"x":299.5,"y":189,"isAttachedTo":"ab2b3","attachmentDisplay":{"position":[0.25,0],"offset":[0,0]},"orientation":[0,1]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge","SBO:0000167","SBO:0000393","SBO:0000394","DirectedInteraction"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"Arrow","isAttachedTo":["f7754","ab2b3"],"burrs":["c531f"]},"c531f":{"attachmentDisplay":{"position":[0.5312887021137447,0],"offset":[0,0]},"drawAs":"none","id":"c531f","isAttachedTo":"ea1de","borderWidth":0,"height":0,"width":0,"zIndex":12288,"type":["Anchor","Burr"],"kaavioType":"Burr","gpmlElementName":"Anchor"},"c8b89":{"id":"c8b89","comments":[{"content":"JNK-1 phosphorylates DAF-16 leading to its translocation to the nucleus."}],"citations":["publicationXreff8b"],"zIndex":32781,"borderWidth":2,"color":"#339900","points":[{"x":192,"y":460,"isAttachedTo":"e2e8a","attachmentDisplay":{"position":[0.5,1],"offset":[0,0]},"orientation":[0,1]},{"x":213,"y":473,"isAttachedTo":"dd9c0","attachmentDisplay":{"position":[0.25,0],"offset":[0,0]},"orientation":[0,1]}],"drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","isAttachedTo":["e2e8a","dd9c0"]},"ffa37":{"id":"ffa37","zIndex":32797,"borderWidth":1,"points":[{"x":288,"y":106,"isAttachedTo":"ee0b6","attachmentDisplay":{"position":[0.75,1],"offset":[0,0]},"orientation":[0,1]},{"x":389,"y":160.75,"isAttachedTo":"bde8d","attachmentDisplay":{"position":[0,0.25],"offset":[0,0]},"orientation":[1,0]}],"color":"#000000","drawAs":"StraightLine","backgroundColor":"none","type":["Interaction","Edge"],"kaavioType":"Edge","gpmlElementName":"Interaction","markerEnd":"MimInhibition","isAttachedTo":["ee0b6","bde8d"]},"a59bc":{"id":"a59bc","textAlign":"center","color":"#808080","verticalAlign":"middle","fontSize":1,"fontWeight":"bold","borderWidth":0,"fillOpacity":0.1,"padding":8,"drawAs":"none","strokeDasharray":"5,3","backgroundColor":"transparent","type":["Group","GroupGroup"],"contains":["be992","a64c1"],"kaavioType":"Group","gpmlElementName":"Group","zIndex":32773,"x":316,"y":326,"width":180,"height":36},"a3e69":{"id":"a3e69","textAlign":"center","color":"#808080","verticalAlign":"middle","fontSize":1,"fontWeight":"bold","borderWidth":1,"fillOpacity":0.1,"padding":11,"drawAs":"Octagon","backgroundColor":"#b4b464","type":["Group","Complex","GroupComplex"],"contains":["e9b6a","fc419"],"kaavioType":"Group","gpmlElementName":"Group","zIndex":32768,"x":518,"y":420,"width":104,"height":80}}}
|