/**
 * @fileoverview Defines the core logic, schemas, and types for the `clinicaltrials_search_studies` tool.
 * @module src/mcp-server/tools/searchStudies/logic
 */
import { z } from "zod";
import { type RequestContext } from "../../../utils/index.js";
/**
 * Zod schema for the `clinicaltrials_search_studies` tool input.
 */
export declare const SearchStudiesInputSchema: z.ZodObject<{
    query: z.ZodOptional<z.ZodObject<{
        cond: z.ZodOptional<z.ZodString>;
        term: z.ZodOptional<z.ZodString>;
        locn: z.ZodOptional<z.ZodString>;
        titles: z.ZodOptional<z.ZodString>;
        intr: z.ZodOptional<z.ZodString>;
        outc: z.ZodOptional<z.ZodString>;
        spons: z.ZodOptional<z.ZodString>;
        id: z.ZodOptional<z.ZodString>;
    }, "strip", z.ZodTypeAny, {
        id?: string | undefined;
        cond?: string | undefined;
        term?: string | undefined;
        locn?: string | undefined;
        titles?: string | undefined;
        intr?: string | undefined;
        outc?: string | undefined;
        spons?: string | undefined;
    }, {
        id?: string | undefined;
        cond?: string | undefined;
        term?: string | undefined;
        locn?: string | undefined;
        titles?: string | undefined;
        intr?: string | undefined;
        outc?: string | undefined;
        spons?: string | undefined;
    }>>;
    filter: z.ZodOptional<z.ZodObject<{
        ids: z.ZodOptional<z.ZodArray<z.ZodString, "many">>;
        overallStatus: z.ZodOptional<z.ZodArray<z.ZodEnum<["ACTIVE_NOT_RECRUITING", "COMPLETED", "ENROLLING_BY_INVITATION", "NOT_YET_RECRUITING", "RECRUITING", "SUSPENDED", "TERMINATED", "WITHDRAWN", "UNKNOWN"]>, "many">>;
        geo: z.ZodOptional<z.ZodObject<{
            latitude: z.ZodNumber;
            longitude: z.ZodNumber;
            radius: z.ZodNumber;
            unit: z.ZodDefault<z.ZodEnum<["km", "mi"]>>;
        }, "strip", z.ZodTypeAny, {
            latitude: number;
            longitude: number;
            radius: number;
            unit: "km" | "mi";
        }, {
            latitude: number;
            longitude: number;
            radius: number;
            unit?: "km" | "mi" | undefined;
        }>>;
        advanced: z.ZodOptional<z.ZodString>;
    }, "strip", z.ZodTypeAny, {
        overallStatus?: ("ACTIVE_NOT_RECRUITING" | "COMPLETED" | "ENROLLING_BY_INVITATION" | "NOT_YET_RECRUITING" | "RECRUITING" | "SUSPENDED" | "TERMINATED" | "WITHDRAWN" | "UNKNOWN")[] | undefined;
        ids?: string[] | undefined;
        geo?: {
            latitude: number;
            longitude: number;
            radius: number;
            unit: "km" | "mi";
        } | undefined;
        advanced?: string | undefined;
    }, {
        overallStatus?: ("ACTIVE_NOT_RECRUITING" | "COMPLETED" | "ENROLLING_BY_INVITATION" | "NOT_YET_RECRUITING" | "RECRUITING" | "SUSPENDED" | "TERMINATED" | "WITHDRAWN" | "UNKNOWN")[] | undefined;
        ids?: string[] | undefined;
        geo?: {
            latitude: number;
            longitude: number;
            radius: number;
            unit?: "km" | "mi" | undefined;
        } | undefined;
        advanced?: string | undefined;
    }>>;
    fields: z.ZodOptional<z.ZodArray<z.ZodString, "many">>;
    sort: z.ZodOptional<z.ZodArray<z.ZodString, "many">>;
    pageSize: z.ZodOptional<z.ZodDefault<z.ZodNumber>>;
    pageToken: z.ZodOptional<z.ZodString>;
}, "strip", z.ZodTypeAny, {
    sort?: string[] | undefined;
    filter?: {
        overallStatus?: ("ACTIVE_NOT_RECRUITING" | "COMPLETED" | "ENROLLING_BY_INVITATION" | "NOT_YET_RECRUITING" | "RECRUITING" | "SUSPENDED" | "TERMINATED" | "WITHDRAWN" | "UNKNOWN")[] | undefined;
        ids?: string[] | undefined;
        geo?: {
            latitude: number;
            longitude: number;
            radius: number;
            unit: "km" | "mi";
        } | undefined;
        advanced?: string | undefined;
    } | undefined;
    fields?: string[] | undefined;
    query?: {
        id?: string | undefined;
        cond?: string | undefined;
        term?: string | undefined;
        locn?: string | undefined;
        titles?: string | undefined;
        intr?: string | undefined;
        outc?: string | undefined;
        spons?: string | undefined;
    } | undefined;
    pageSize?: number | undefined;
    pageToken?: string | undefined;
}, {
    sort?: string[] | undefined;
    filter?: {
        overallStatus?: ("ACTIVE_NOT_RECRUITING" | "COMPLETED" | "ENROLLING_BY_INVITATION" | "NOT_YET_RECRUITING" | "RECRUITING" | "SUSPENDED" | "TERMINATED" | "WITHDRAWN" | "UNKNOWN")[] | undefined;
        ids?: string[] | undefined;
        geo?: {
            latitude: number;
            longitude: number;
            radius: number;
            unit?: "km" | "mi" | undefined;
        } | undefined;
        advanced?: string | undefined;
    } | undefined;
    fields?: string[] | undefined;
    query?: {
        id?: string | undefined;
        cond?: string | undefined;
        term?: string | undefined;
        locn?: string | undefined;
        titles?: string | undefined;
        intr?: string | undefined;
        outc?: string | undefined;
        spons?: string | undefined;
    } | undefined;
    pageSize?: number | undefined;
    pageToken?: string | undefined;
}>;
/**
 * TypeScript type inferred from the input schema.
 */
export type SearchStudiesInput = z.infer<typeof SearchStudiesInputSchema>;
/**
 * Zod schema for the output of the `clinicaltrials_search_studies` tool.
 */
export declare const SearchStudiesOutputSchema: z.ZodObject<{
    studies: z.ZodArray<z.ZodObject<{
        protocolSection: z.ZodOptional<z.ZodObject<{
            identificationModule: z.ZodOptional<z.ZodObject<{
                nctId: z.ZodString;
                orgStudyIdInfo: z.ZodOptional<z.ZodObject<{
                    id: z.ZodString;
                }, "strip", z.ZodTypeAny, {
                    id: string;
                }, {
                    id: string;
                }>>;
                organization: z.ZodOptional<z.ZodObject<{
                    fullName: z.ZodString;
                    class: z.ZodString;
                }, "strip", z.ZodTypeAny, {
                    class: string;
                    fullName: string;
                }, {
                    class: string;
                    fullName: string;
                }>>;
                briefTitle: z.ZodOptional<z.ZodString>;
                officialTitle: z.ZodOptional<z.ZodString>;
                acronym: z.ZodOptional<z.ZodString>;
            }, "strip", z.ZodTypeAny, {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            }, {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            }>>;
            statusModule: z.ZodOptional<z.ZodObject<{
                overallStatus: z.ZodOptional<z.ZodString>;
                lastKnownStatus: z.ZodOptional<z.ZodString>;
                startDateStruct: z.ZodOptional<z.ZodObject<{
                    date: z.ZodString;
                    type: z.ZodOptional<z.ZodString>;
                }, "strip", z.ZodTypeAny, {
                    date: string;
                    type?: string | undefined;
                }, {
                    date: string;
                    type?: string | undefined;
                }>>;
                primaryCompletionDateStruct: z.ZodOptional<z.ZodObject<{
                    date: z.ZodString;
                    type: z.ZodOptional<z.ZodString>;
                }, "strip", z.ZodTypeAny, {
                    date: string;
                    type?: string | undefined;
                }, {
                    date: string;
                    type?: string | undefined;
                }>>;
                completionDateStruct: z.ZodOptional<z.ZodObject<{
                    date: z.ZodString;
                    type: z.ZodOptional<z.ZodString>;
                }, "strip", z.ZodTypeAny, {
                    date: string;
                    type?: string | undefined;
                }, {
                    date: string;
                    type?: string | undefined;
                }>>;
            }, "strip", z.ZodTypeAny, {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            }, {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            }>>;
            sponsorCollaboratorsModule: z.ZodOptional<z.ZodObject<{
                responsibleParty: z.ZodOptional<z.ZodObject<{
                    type: z.ZodString;
                }, "strip", z.ZodTypeAny, {
                    type: string;
                }, {
                    type: string;
                }>>;
                leadSponsor: z.ZodOptional<z.ZodObject<{
                    name: z.ZodString;
                    class: z.ZodString;
                }, "strip", z.ZodTypeAny, {
                    name: string;
                    class: string;
                }, {
                    name: string;
                    class: string;
                }>>;
                collaborators: z.ZodOptional<z.ZodArray<z.ZodObject<{
                    name: z.ZodString;
                    class: z.ZodString;
                }, "strip", z.ZodTypeAny, {
                    name: string;
                    class: string;
                }, {
                    name: string;
                    class: string;
                }>, "many">>;
            }, "strip", z.ZodTypeAny, {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            }, {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            }>>;
            descriptionModule: z.ZodOptional<z.ZodObject<{
                briefSummary: z.ZodOptional<z.ZodString>;
                detailedDescription: z.ZodOptional<z.ZodString>;
            }, "strip", z.ZodTypeAny, {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            }, {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            }>>;
            conditionsModule: z.ZodOptional<z.ZodObject<{
                conditions: z.ZodOptional<z.ZodArray<z.ZodString, "many">>;
                keywords: z.ZodOptional<z.ZodArray<z.ZodString, "many">>;
            }, "strip", z.ZodTypeAny, {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            }, {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            }>>;
            armsInterventionsModule: z.ZodOptional<z.ZodObject<{
                arms: z.ZodOptional<z.ZodArray<z.ZodObject<{
                    name: z.ZodString;
                    type: z.ZodString;
                    description: z.ZodOptional<z.ZodString>;
                }, "strip", z.ZodTypeAny, {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }, {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }>, "many">>;
                interventions: z.ZodOptional<z.ZodArray<z.ZodObject<{
                    type: z.ZodString;
                    name: z.ZodString;
                    description: z.ZodOptional<z.ZodString>;
                    armNames: z.ZodArray<z.ZodString, "many">;
                }, "strip", z.ZodTypeAny, {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }, {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }>, "many">>;
            }, "strip", z.ZodTypeAny, {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            }, {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            }>>;
            designModule: z.ZodOptional<z.ZodObject<{
                studyType: z.ZodOptional<z.ZodString>;
                phases: z.ZodOptional<z.ZodArray<z.ZodString, "many">>;
                designInfo: z.ZodOptional<z.ZodObject<{
                    allocation: z.ZodOptional<z.ZodString>;
                    interventionModel: z.ZodOptional<z.ZodString>;
                    primaryPurpose: z.ZodOptional<z.ZodString>;
                    maskingInfo: z.ZodOptional<z.ZodObject<{
                        masking: z.ZodString;
                    }, "strip", z.ZodTypeAny, {
                        masking: string;
                    }, {
                        masking: string;
                    }>>;
                }, "strip", z.ZodTypeAny, {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                }, {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                }>>;
            }, "strip", z.ZodTypeAny, {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            }, {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            }>>;
            contactsLocationsModule: z.ZodOptional<z.ZodObject<{
                locations: z.ZodOptional<z.ZodArray<z.ZodObject<{
                    city: z.ZodOptional<z.ZodString>;
                    state: z.ZodOptional<z.ZodString>;
                    country: z.ZodOptional<z.ZodString>;
                }, "strip", z.ZodTypeAny, {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }, {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }>, "many">>;
            }, "strip", z.ZodTypeAny, {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            }, {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            }>>;
        }, "strip", z.ZodTypeAny, {
            identificationModule?: {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            } | undefined;
            statusModule?: {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            } | undefined;
            sponsorCollaboratorsModule?: {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            } | undefined;
            descriptionModule?: {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            } | undefined;
            conditionsModule?: {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            } | undefined;
            armsInterventionsModule?: {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            } | undefined;
            designModule?: {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            } | undefined;
            contactsLocationsModule?: {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            } | undefined;
        }, {
            identificationModule?: {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            } | undefined;
            statusModule?: {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            } | undefined;
            sponsorCollaboratorsModule?: {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            } | undefined;
            descriptionModule?: {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            } | undefined;
            conditionsModule?: {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            } | undefined;
            armsInterventionsModule?: {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            } | undefined;
            designModule?: {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            } | undefined;
            contactsLocationsModule?: {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            } | undefined;
        }>>;
    }, "strip", z.ZodTypeAny, {
        protocolSection?: {
            identificationModule?: {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            } | undefined;
            statusModule?: {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            } | undefined;
            sponsorCollaboratorsModule?: {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            } | undefined;
            descriptionModule?: {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            } | undefined;
            conditionsModule?: {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            } | undefined;
            armsInterventionsModule?: {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            } | undefined;
            designModule?: {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            } | undefined;
            contactsLocationsModule?: {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            } | undefined;
        } | undefined;
    }, {
        protocolSection?: {
            identificationModule?: {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            } | undefined;
            statusModule?: {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            } | undefined;
            sponsorCollaboratorsModule?: {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            } | undefined;
            descriptionModule?: {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            } | undefined;
            conditionsModule?: {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            } | undefined;
            armsInterventionsModule?: {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            } | undefined;
            designModule?: {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            } | undefined;
            contactsLocationsModule?: {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            } | undefined;
        } | undefined;
    }>, "many">;
    nextPageToken: z.ZodOptional<z.ZodString>;
    totalCount: z.ZodOptional<z.ZodNumber>;
}, "strip", z.ZodTypeAny, {
    studies: {
        protocolSection?: {
            identificationModule?: {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            } | undefined;
            statusModule?: {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            } | undefined;
            sponsorCollaboratorsModule?: {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            } | undefined;
            descriptionModule?: {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            } | undefined;
            conditionsModule?: {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            } | undefined;
            armsInterventionsModule?: {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            } | undefined;
            designModule?: {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            } | undefined;
            contactsLocationsModule?: {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            } | undefined;
        } | undefined;
    }[];
    nextPageToken?: string | undefined;
    totalCount?: number | undefined;
}, {
    studies: {
        protocolSection?: {
            identificationModule?: {
                nctId: string;
                orgStudyIdInfo?: {
                    id: string;
                } | undefined;
                organization?: {
                    class: string;
                    fullName: string;
                } | undefined;
                briefTitle?: string | undefined;
                officialTitle?: string | undefined;
                acronym?: string | undefined;
            } | undefined;
            statusModule?: {
                overallStatus?: string | undefined;
                lastKnownStatus?: string | undefined;
                startDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                primaryCompletionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
                completionDateStruct?: {
                    date: string;
                    type?: string | undefined;
                } | undefined;
            } | undefined;
            sponsorCollaboratorsModule?: {
                responsibleParty?: {
                    type: string;
                } | undefined;
                leadSponsor?: {
                    name: string;
                    class: string;
                } | undefined;
                collaborators?: {
                    name: string;
                    class: string;
                }[] | undefined;
            } | undefined;
            descriptionModule?: {
                briefSummary?: string | undefined;
                detailedDescription?: string | undefined;
            } | undefined;
            conditionsModule?: {
                conditions?: string[] | undefined;
                keywords?: string[] | undefined;
            } | undefined;
            armsInterventionsModule?: {
                arms?: {
                    type: string;
                    name: string;
                    description?: string | undefined;
                }[] | undefined;
                interventions?: {
                    type: string;
                    name: string;
                    armNames: string[];
                    description?: string | undefined;
                }[] | undefined;
            } | undefined;
            designModule?: {
                studyType?: string | undefined;
                phases?: string[] | undefined;
                designInfo?: {
                    allocation?: string | undefined;
                    interventionModel?: string | undefined;
                    primaryPurpose?: string | undefined;
                    maskingInfo?: {
                        masking: string;
                    } | undefined;
                } | undefined;
            } | undefined;
            contactsLocationsModule?: {
                locations?: {
                    city?: string | undefined;
                    state?: string | undefined;
                    country?: string | undefined;
                }[] | undefined;
            } | undefined;
        } | undefined;
    }[];
    nextPageToken?: string | undefined;
    totalCount?: number | undefined;
}>;
/**
 * TypeScript type inferred from the output schema.
 */
export type SearchStudiesOutput = z.infer<typeof SearchStudiesOutputSchema>;
/**
 * Searches for clinical studies using a combination of queries and filters.
 * Supports pagination, sorting, and geographic filtering.
 *
 * @param params - The validated input parameters for the tool.
 * @param context - The request context for logging and tracing.
 * @returns A promise that resolves with a paginated list of studies.
 * @throws {McpError} If the API request fails.
 */
export declare function searchStudiesLogic(params: SearchStudiesInput, context: RequestContext): Promise<SearchStudiesOutput>;