{
  "Name": "Albuterol",
  "Density": {
    "ScalarMassPerVolume": {
      "Value": 3213.0,
      "Unit": "g/m^3"
    }
  },
  "MolarMass": {
    "ScalarMassPerAmount": {
      "Value": 239.31,
      "Unit": "g/mol"
    }
  },
  "State": "Liquid",
  "Aerosolization": {
    "BronchioleModifier": {
      "ScalarNegative1To1": {
        "Value": 1.0
      }
    },
    "InflammationCoefficient": {
      "Scalar0To1": {
      }
    },
    "ParticulateSizeDistribution": {
      "HistogramFractionVsLength": {
        "Histogram": {
          "Dependent": {
            "Value": [0.15003, 0.18454, 0.16846, 0.14005, 0.11013, 0.08322, 0.06096, 0.04351, 0.03038, 0.02079, 0.00713, 7.4E-4, 6.0E-5, 0.0]
          },
          "Independent": {
            "Value": [0.0, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 7.0, 8.0, 9.0, 10.0, 15.0, 20.0, 25.0, 30.0]
          },
          "IndependentUnit": "um"
        }
      }
    }
  },
  "RelativeDiffusionCoefficient": {
    "Value": 0.047
  },
  "SolubilityCoefficient": {
    "ScalarInversePressure": {
      "Value": 0.46,
      "Unit": "1/atm"
    }
  },
  "Clearance": {
    "SystemicClearance": {
      "FractionExcretedInFeces": {
        "Scalar0To1": {
          "Value": 0.2
        }
      },
      "FractionUnboundInPlasma": {
        "Scalar0To1": {
          "Value": 0.9
        }
      },
      "IntrinsicClearance": {
        "ScalarVolumePerTimeMass": {
          "Unit": "mL/min kg"
        }
      },
      "RenalClearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 0.2,
          "Unit": "mL/min kg"
        }
      },
      "SystemicClearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 1.0,
          "Unit": "mL/min kg"
        }
      }
    },
    "RenalClearance": {
      "Clearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 0.2,
          "Unit": "mL/min kg"
        }
      }
    }
  },
  "Pharmacokinetics": {
    "TissueKinetics": [{
      "Name": "GutTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "LeftKidneyTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "MuscleTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "SkinTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "LiverTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "MyocardiumTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "RightLungTissue",
      "PartitionCoefficient": {
        "Value": 4.0
      }
    }, {
      "Name": "BrainTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "BoneTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "LeftLungTissue",
      "PartitionCoefficient": {
        "Value": 4.0
      }
    }, {
      "Name": "FatTissue",
      "PartitionCoefficient": {
        "Value": 2.0
      }
    }, {
      "Name": "RightKidneyTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }, {
      "Name": "SpleenTissue",
      "PartitionCoefficient": {
        "Value": 1.0
      }
    }]
  },
  "Pharmacodynamics": {
    "Bronchodilation": {
      "ScalarNegative1To1": {
      }
    },
    "DiastolicPressureModifier": {
      "ScalarNegative1To1": {
      }
    },
    "EC50": {
      "ScalarMassPerVolume": {
        "Value": 3.1E-5,
        "Unit": "ug/mL"
      }
    },
    "EMaxShapeParameter": {
      "Value": 1.0
    },
    "HeartRateModifier": {
      "ScalarNegative1To1": {
        "Value": 0.3
      }
    },
    "NeuromuscularBlock": {
      "ScalarNegative1To1": {
      }
    },
    "PupillaryResponse": {
      "ReactivityModifier": {
        "ScalarNegative1To1": {
          "Value": -0.5
        }
      },
      "SizeModifier": {
        "ScalarNegative1To1": {
          "Value": 0.5
        }
      }
    },
    "RespirationRateModifier": {
      "ScalarNegative1To1": {
        "Value": 0.2
      }
    },
    "Sedation": {
      "ScalarNegative1To1": {
      }
    },
    "SystolicPressureModifier": {
      "ScalarNegative1To1": {
      }
    },
    "TidalVolumeModifier": {
      "ScalarNegative1To1": {
      }
    },
    "TubularPermeabilityModifier": {
      "ScalarNegative1To1": {
      }
    }
  }
}