{
  "Name": "Furosemide",
  "MolarMass": {
    "ScalarMassPerAmount": {
      "Value": 330.74,
      "Unit": "g/mol"
    }
  },
  "State": "Liquid",
  "Clearance": {
    "SystemicClearance": {
      "FractionExcretedInFeces": {
        "Scalar0To1": {
          "Value": 0.08
        }
      },
      "FractionUnboundInPlasma": {
        "Scalar0To1": {
          "Value": 0.05
        }
      },
      "IntrinsicClearance": {
        "ScalarVolumePerTimeMass": {
          "Unit": "mL/min kg"
        }
      },
      "RenalClearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 2.25,
          "Unit": "mL/min kg"
        }
      },
      "SystemicClearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 4.62,
          "Unit": "mL/min kg"
        }
      }
    },
    "RenalClearance": {
      "Clearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 2.25,
          "Unit": "mL/min kg"
        }
      }
    }
  },
  "Pharmacokinetics": {
    "Physicochemicals": {
      "AcidDissociationConstant": {
        "Value": 3.0
      },
      "BindingProtein": "Albumin",
      "BloodPlasmaRatio": {
        "Value": 0.75
      },
      "FractionUnboundInPlasma": {
        "Scalar0To1": {
          "Value": 0.05
        }
      },
      "IonicState": "Acid",
      "LogP": {
        "Value": 2.03
      }
    }
  },
  "Pharmacodynamics": {
    "Bronchodilation": {
      "ScalarNegative1To1": {
      }
    },
    "DiastolicPressureModifier": {
      "ScalarNegative1To1": {
      }
    },
    "EC50": {
      "ScalarMassPerVolume": {
        "Value": 0.4462,
        "Unit": "ug/mL"
      }
    },
    "EMaxShapeParameter": {
      "Value": 1.0
    },
    "HeartRateModifier": {
      "ScalarNegative1To1": {
      }
    },
    "NeuromuscularBlock": {
      "ScalarNegative1To1": {
      }
    },
    "PupillaryResponse": {
      "ReactivityModifier": {
        "ScalarNegative1To1": {
        }
      },
      "SizeModifier": {
        "ScalarNegative1To1": {
        }
      }
    },
    "RespirationRateModifier": {
      "ScalarNegative1To1": {
      }
    },
    "Sedation": {
      "ScalarNegative1To1": {
      }
    },
    "SystolicPressureModifier": {
      "ScalarNegative1To1": {
      }
    },
    "TidalVolumeModifier": {
      "ScalarNegative1To1": {
      }
    },
    "TubularPermeabilityModifier": {
      "ScalarNegative1To1": {
        "Value": 0.8
      }
    }
  }
}