{
  "Name": "Lorazepam",
  "MolarMass": {
    "ScalarMassPerAmount": {
      "Value": 321.16,
      "Unit": "g/mol"
    }
  },
  "State": "Liquid",
  "Clearance": {
    "SystemicClearance": {
      "FractionExcretedInFeces": {
        "Scalar0To1": {
          "Value": 0.07
        }
      },
      "FractionUnboundInPlasma": {
        "Scalar0To1": {
          "Value": 0.1
        }
      },
      "IntrinsicClearance": {
        "ScalarVolumePerTimeMass": {
          "Unit": "mL/min kg"
        }
      },
      "RenalClearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 0.05,
          "Unit": "mL/min kg"
        }
      },
      "SystemicClearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 0.25,
          "Unit": "mL/min kg"
        }
      }
    },
    "RenalClearance": {
      "Clearance": {
        "ScalarVolumePerTimeMass": {
          "Value": 0.05,
          "Unit": "mL/min kg"
        }
      }
    }
  },
  "Pharmacokinetics": {
    "TissueKinetics": [{
      "Name": "GutTissue",
      "PartitionCoefficient": {
        "Value": 7.359799999999999
      }
    }, {
      "Name": "LeftKidneyTissue",
      "PartitionCoefficient": {
        "Value": 6.7242
      }
    }, {
      "Name": "MuscleTissue",
      "PartitionCoefficient": {
        "Value": 5.8268
      }
    }, {
      "Name": "SkinTissue",
      "PartitionCoefficient": {
        "Value": 9.0272
      }
    }, {
      "Name": "LiverTissue",
      "PartitionCoefficient": {
        "Value": 6.078799999999999
      }
    }, {
      "Name": "MyocardiumTissue",
      "PartitionCoefficient": {
        "Value": 7.252000000000001
      }
    }, {
      "Name": "RightLungTissue",
      "PartitionCoefficient": {
        "Value": 8.4336
      }
    }, {
      "Name": "BrainTissue",
      "PartitionCoefficient": {
        "Value": 5.579000000000001
      }
    }, {
      "Name": "BoneTissue",
      "PartitionCoefficient": {
        "Value": 4.7908
      }
    }, {
      "Name": "LeftLungTissue",
      "PartitionCoefficient": {
        "Value": 8.4336
      }
    }, {
      "Name": "FatTissue",
      "PartitionCoefficient": {
        "Value": 1.6506
      }
    }, {
      "Name": "RightKidneyTissue",
      "PartitionCoefficient": {
        "Value": 6.7242
      }
    }, {
      "Name": "SpleenTissue",
      "PartitionCoefficient": {
        "Value": 10.4496
      }
    }]
  },
  "Pharmacodynamics": {
    "Bronchodilation": {
      "ScalarNegative1To1": {
      }
    },
    "DiastolicPressureModifier": {
      "ScalarNegative1To1": {
        "Value": -0.25
      }
    },
    "EC50": {
      "ScalarMassPerVolume": {
        "Value": 0.4558,
        "Unit": "ug/mL"
      }
    },
    "EMaxShapeParameter": {
      "Value": 1.0
    },
    "HeartRateModifier": {
      "ScalarNegative1To1": {
        "Value": -0.15
      }
    },
    "NeuromuscularBlock": {
      "ScalarNegative1To1": {
      }
    },
    "PupillaryResponse": {
      "ReactivityModifier": {
        "ScalarNegative1To1": {
        }
      },
      "SizeModifier": {
        "ScalarNegative1To1": {
        }
      }
    },
    "RespirationRateModifier": {
      "ScalarNegative1To1": {
        "Value": -0.35
      }
    },
    "Sedation": {
      "ScalarNegative1To1": {
        "Value": 0.5
      }
    },
    "SystolicPressureModifier": {
      "ScalarNegative1To1": {
        "Value": -0.25
      }
    },
    "TidalVolumeModifier": {
      "ScalarNegative1To1": {
        "Value": -0.25
      }
    },
    "TubularPermeabilityModifier": {
      "ScalarNegative1To1": {
      }
    }
  }
}