import { ICodeableConcept, IElement, IAnnotation, AllergyIntoleranceSeverityType } from 'fhirtypes/dist/r4';
import { AllergyIntoleranceReaction } from '../../models';
import { BackboneBuilder, IBuildable } from '../base';
import { ExtractUnderscoreKeys } from '../../../core/commons/utils';
type PrimitiveExtensionFields = ExtractUnderscoreKeys<AllergyIntoleranceReaction>;
/**
 * @description Interface for chaining the building of a AllergyIntoleranceReaction
 * @interface IAllergyIntoleranceReactionBuilder
 * @extends {IBuildable<AllergyIntoleranceReaction>}
 */
interface IAllergyIntoleranceReactionBuilder extends IBuildable<AllergyIntoleranceReaction> {
    setSubstance(value: ICodeableConcept): this;
    addManifestation(value: ICodeableConcept): this;
    setDescription(value: string): this;
    setOnset(value: string): this;
    setSeverity(value: AllergyIntoleranceSeverityType): this;
    setExposureRoute(value: ICodeableConcept): this;
    addNote(value: IAnnotation): this;
}
/**
 * @version R4 (v4.0.1)
 * @summary FHIR® Specification by HL7®
 * @description Class for building a AllergyIntoleranceReaction
 * @class AllergyIntoleranceReactionBuilder
 * @extends {BackboneBuilder}
 * @implements {IAllergyIntoleranceReactionBuilder}
 * @author Roberto Araneda Espinoza
 */
export declare class AllergyIntoleranceReactionBuilder extends BackboneBuilder implements IAllergyIntoleranceReactionBuilder {
    private readonly allergyIntoleranceReaction;
    constructor();
    /**
     * @description Adds a primitive extension to the element
     * @param param - the field to add the extension to
     * @param extension - the extension to add
     * @returns {this}
     * @example addPrimitiveExtension('_value', { value: 'test' })
     */
    addPrimitiveExtension(param: PrimitiveExtensionFields, extension: IElement): this;
    /**
     * @description Builds the model
     * @returns {AllergyIntoleranceReaction}
     */
    build(): AllergyIntoleranceReaction;
    /**
     * @description Sets the substance value
     * @description Identification of the specific substance (or pharmaceutical product) considered to be responsible for the Adverse Reaction event. Note: the substance for a specific reaction may be different from the substance identified as the cause of the risk, but it must be consistent with it. For instance, it may be a more specific substance (e.g. a brand medication) or a composite product that includes the identified substance. It must be clinically safe to only process the 'code' and ignore the 'reaction.substance'.  If a receiving system is unable to confirm that AllergyIntolerance.reaction.substance falls within the semantic scope of AllergyIntolerance.code, then the receiving system should ignore AllergyIntolerance.reaction.substance.
     * @param value - the value to set
     * @returns {this}
     */
    setSubstance(value: ICodeableConcept): this;
    /**
     * @description Adds a value to the manifestation array
     * @description Clinical symptoms and/or signs that are observed or associated with the adverse reaction event.
     * @param value - the value to add
     * @returns {this}
     */
    addManifestation(value: ICodeableConcept): this;
    /**
     * @description Sets the description value
     * @description Text description about the reaction as a whole, including details of the manifestation if required.
     * @param value - the value to set
     * @returns {this}
     */
    setDescription(value: string): this;
    /**
     * @description Sets the onset value
     * @description Record of the date and/or time of the onset of the Reaction.
     * @param value - the value to set
     * @returns {this}
     */
    setOnset(value: string): this;
    /**
      * @description Sets the severity value
      * @description Clinical assessment of the severity of the reaction event as a whole, potentially considering multiple different manifestations.
  mild | moderate | severe.
      * @param value - the value to set
      * @returns {this}
      */
    setSeverity(value: AllergyIntoleranceSeverityType): this;
    /**
     * @description Sets the exposureRoute value
     * @description Identification of the route by which the subject was exposed to the substance.
     * @param value - the value to set
     * @returns {this}
     */
    setExposureRoute(value: ICodeableConcept): this;
    /**
     * @description Adds a value to the note array
     * @description Additional text about the adverse reaction event not captured in other fields.
     * @param value - the value to add
     * @returns {this}
     */
    addNote(value: IAnnotation): this;
}
export {};