import { ICodeableConcept, IElement, IAnnotation, AllergyIntoleranceSeverityType } from 'fhirtypes/dist/r4';
import { IAllergyIntoleranceReaction, IOperationOutcome } from 'fhirtypes/dist/r4';
import { BackboneElement, IValidatable, ISerializable } from '../base';
/**
 * @version R4 (v4.0.1)
 * @summary FHIR® Specification by HL7®
 * @description Class for AllergyIntoleranceReaction BackboneElement
 * @property {ICodeableConcept} substance
 * @property {ICodeableConcept[]} manifestation
 * @property {string} description
 * @property {IElement} _description
 * @property {string} onset
 * @property {IElement} _onset
 * @property {AllergyIntoleranceSeverityType} severity
 * @property {IElement} _severity
 * @property {ICodeableConcept} exposureRoute
 * @property {IAnnotation[]} note
 * @author Roberto Araneda Espinoza
 */
export declare class AllergyIntoleranceReaction extends BackboneElement implements IAllergyIntoleranceReaction, IValidatable, ISerializable {
    /**
     * @description Identification of the specific substance (or pharmaceutical product) considered to be responsible for the Adverse Reaction event. Note: the substance for a specific reaction may be different from the substance identified as the cause of the risk, but it must be consistent with it. For instance, it may be a more specific substance (e.g. a brand medication) or a composite product that includes the identified substance. It must be clinically safe to only process the 'code' and ignore the 'reaction.substance'.  If a receiving system is unable to confirm that AllergyIntolerance.reaction.substance falls within the semantic scope of AllergyIntolerance.code, then the receiving system should ignore AllergyIntolerance.reaction.substance.
     */
    substance?: ICodeableConcept;
    /**
     * @description Clinical symptoms and/or signs that are observed or associated with the adverse reaction event.
     */
    manifestation: ICodeableConcept[];
    /**
     * @description Text description about the reaction as a whole, including details of the manifestation if required.
     */
    description?: string;
    /**
     * @description Extensions for description
     */
    _description?: IElement;
    /**
     * @description Record of the date and/or time of the onset of the Reaction.
     */
    onset?: string;
    /**
     * @description Extensions for onset
     */
    _onset?: IElement;
    /**
     * @description Clinical assessment of the severity of the reaction event as a whole, potentially considering multiple different manifestations.
  mild | moderate | severe.
     */
    severity?: AllergyIntoleranceSeverityType;
    /**
     * @description Extensions for severity
     */
    _severity?: IElement;
    /**
     * @description Identification of the route by which the subject was exposed to the substance.
     */
    exposureRoute?: ICodeableConcept;
    /**
     * @description Additional text about the adverse reaction event not captured in other fields.
     */
    note?: IAnnotation[];
    /**
     * @description Returns a JSON representation of the model
     * @returns {Record<string, any>}
     */
    toJson(): Record<string, any>;
    /**
     * @description Returns a string representation of the model
     * @returns {string}
     */
    toString(): string;
    /**
     * @description Returns a pretty string representation of the model
     * @returns {string}
     */
    toPrettyString(): string;
    /**
     * @description Returns a serialized string representation of the model
     * @returns {string}
     */
    serialize(): string;
    /**
     * @description Validates the model
     * @returns {isValid: boolean, operationOutcome: IOperationOutcome}
     */
    validate(): {
        isValid: boolean;
        operationOutcome: IOperationOutcome;
    };
    constructor(args?: IAllergyIntoleranceReaction);
}