import { IBackboneElement, IElement } from '../base';
import { IAnnotation, ICodeableConcept } from '../datatypes';
import { AllergyIntoleranceSeverityType } from '../types';
export interface IAllergyIntoleranceReaction extends IBackboneElement {
    /**
     * @description Identification of the specific substance (or pharmaceutical product) considered to be responsible for the Adverse Reaction event.
     */
    substance?: ICodeableConcept;
    /**
     * @description Clinical symptoms and/or signs that are observed or associated with the adverse reaction event.
     */
    manifestation: ICodeableConcept[];
    /**
     * @description Text description about the reaction as a whole, including details of the manifestation if required.
     */
    description?: string;
    /**
     * @description Record of the date and/or time of the onset of the reaction.
     */
    onset?: string;
    /**
     * @description Clinical assessment of the severity of the reaction event as a whole, potentially considering multiple different manifestations.
     */
    severity?: AllergyIntoleranceSeverityType;
    /**
     * @description Identification of the route by which the subject was exposed to the substance.
     */
    exposureRoute?: ICodeableConcept;
    /**
     * @description Additional text about the adverse reaction event not captured in other fields.
     */
    note?: IAnnotation[];
    /**
     * @description Extension for description
     */
    _description?: IElement;
    /**
     * @description Extension for onset
     */
    _onset?: IElement;
    /**
     * @description Extension for severity
     */
    _severity?: IElement;
}